| Japanese |
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| Title | 甲状腺ホルモン投与による心筋虚血再灌流時の超微形態と代謝に及ぼす影響 |
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| Subtitle | 原著 |
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| Authors | 片山康 |
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| Organization | 獨協医科大学越谷病院心臓血管外科 |
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| Journal | 循環制御 |
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| Volume | 19 |
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| Number | 1 |
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| Page | 76-82 |
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| Year/Month | 1998/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」開心術後モデル実験動物を使用し, 甲状腺ホルモンtriiodothyronine(T3)0.1μg/kg/minを経静脈性に投与したT3投与群(n=9)と非投与の対照群(n=7)について心筋虚血再灌流時の超微形態と心筋代謝に及ぼす影響を検討した. 両群ともに虚血再灌流後にミトコンドリアの断面積, 周囲長の増加, 形状係数悪化など, stunned myocardiumの状態に陥ったが, T3投与群では障害が軽微であった. 心筋代謝ではT3投与群で心筋酸素摂取, 心筋ブドウ糖摂取の増加がみられた. 甲状腺ホルモン投与は心筋虚血再灌流障害を抑制し, 心筋代謝の活性化によって心筋保護効果を有する結果が得られた. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | Thyroid hormone, Reperfusion injury, Ultrastructure, Myocardial metabolism |
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| English |
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| Title | Effect of Thyroid Hormone on the Ultrastructure and Myocardial Metabolism of the Postischemic Reperfusion Injury |
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| Subtitle | |
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| Authors | Yasushi Katayama |
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| Authors(kana) | |
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| Organization | Department of Cardiovascular and Thoracic Surgery, Dokkyo University Koshigaya Hospital |
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| Journal | Circulation Control |
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| Volume | 19 |
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| Number | 1 |
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| Page | 76-82 |
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| Year/Month | 1998/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | The effect of triiodothyronine (T3) on the myocardial ultrastructure and metabolism was studied using dogs with 60 minutes of normothermic global ischemia and 120 minutes of reperfusion. Dogs were divided into 2 groups ; Control group (n=7) and T3 group (n=9) with an intravenous administration of T3 (0.1μg/Kg/min)immediately after cross-clamping of the aorta. Myocardial ultrastructure and metabolism was studied before cross-clamping of the aorta, at declamping and 120 minutes after reperfusion of the heart. Control group showed mitochondrial swelling, low uptake of oxygen and glucose, while T3 group showed slight changes in the morphology of mitochondria and considerably higher myocardial uptake of oxygen and glucose in the reperfusion period. From these studies, it is concluded that T3 infusion during global ischemia and reperfusion period preserved mitochondrial ultrastructural morphology and resulted in the increased rate of myocardial substrates uptake. |
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| Practice | Basic medicine |
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| Keywords | Thyroid hormone, Reperfusion injury, Ultrastructure, Myocardial metabolism |
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