| Japanese |
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| Title | 冠動脈バイパス術人工心肺離脱時のアムリノン, ミルリノン, オルプリノン投与の相違 |
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| Authors | 謝慶一*, 下川充*, 川口昌彦*, 岩阪友俗*, 呉原弘吉*, 井上聡己*, 北口勝康*, 古家仁* |
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| Organization | *奈良県立医科大学麻酔科学教室 |
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| Journal | 循環制御 |
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| Volume | 19 |
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| Number | 3 |
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| Page | 402-405 |
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| Year/Month | 1998/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」予定成人冠動脈バイパス術45例を対象とし, 人工心肺離脱時にアムリノン, ミルリノンまたはオルプリノンのいずれかを無作為に投与し血行動態及び併用カテコラミンを三剤で比較した. 血行動態測定は手術開始後血行動態安定時(C0), 心肺離脱後血行動態安定時(C1), 閉胸後(C2)に行った. 併用カテコラミンは基本的にドパミン, ノルエピネフリン, ドブタミンの順で選択し, 平均動脈圧を60mmHg, 心係数を3.0l・min-1・m-2以上に維持するよう担当麻酔科医が調節した. 結果は併用カテコラミン量でミルリノンがアムリノン, オルプリノンに比べC1, C2で有意にドパミン, ノルエピネフリンがともに低量であった. ミルリノンはアムリノンおよびオルプリノンに比べ陽性変力作用が強く, 血管拡張作用が弱いことが示唆された. |
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| Practice | 基礎医学・関連科学 |
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| English |
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| Title | Differences among Amrinone, Milrinone and Olprinone on Hemodynamics and Combined Catecholamines Use after Cardiopulmonaly Bypass in Aorta-Coronary Bypass Surgery |
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| Authors | Keiichi Sha*, Mitsuru Simokawa*, Masahiko Kawaguchi*, Tomohiro Iwasaka*, Koukiti Kurehara*, Satoki Inoue*, Katsuyasu Kitaguchi*, Hitoshi Furuya* |
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| Authors(kana) | |
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| Organization | *Department of Anesthesiology, Nara Medical University |
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| Journal | Circulation Control |
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| Volume | 19 |
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| Number | 3 |
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| Page | 402-405 |
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| Year/Month | 1998/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | Fourty five patients who underwent aorta-coronary bypass surgery were evaluated about the differences among amrinine, milrinone and olprione on hemodynamics and combined catecholamines use after cardiopulmonary bypass (CPB). Patients were randomly allocated to three groups; group A was infused amrinone (15 patients); group M was infused milrinone (15 patients); group O was infused olprinone (15 patients). Each drug were administrated as a single dose into the venous reservoir of the CPB circuit 15 min prior to the end of emergence from CPB, followed by an continuous infusion. Hemodynamics were measured at the time of preCPB (C0), postCPB (C1) and after chest closure (C2). Combined cathecholamines were used in the turn of dopamine, norepinephrine and dobutamine. These doses were modulated to maintain the mean blood pressure > 60 mmHg and the cardiac index > 3.0 l/min/m2 by each anesthesiologist. Hemodynamics (at C0, C1 and C2) and the doses of cathecholamine (at C1 and C2) were compared among the 3 drugs. There were no significant differences on hemodynamics among three drugs. In group M, dopamine and norepinephrine doses were significantly lower than those of group A and group O at C1 and C2. Accordingly, it was considered that milrinone had more inotropic effect and less vasodilative effect compared with amrinone and olprinine. |
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| Practice | Basic medicine |
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| Keywords | Amrinone, Milrinone, Olprinone, Aorta-coronary bypass surgery, Cardiopulmonary bypass |
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