| Japanese |
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| Title | 甲状腺ホルモン+coenzymeQ10投与の心筋代謝に及ぼす影響 |
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| Authors | 村井則之*, 片山康*, 今関隆雄*, 山田崇之*, 権重好*, 吉田浩紹*, 秦一剋*, 佐藤康広*, 垣伸明*, 木山宏*, 長澤城幸*, 佐野英基*, 入江嘉仁* |
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| Authors(kana) | |
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| Organization | *濁協医科大学越谷病院心臓血管外科 |
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| Journal | 循環制御 |
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| Volume | 19 |
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| Number | 4 |
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| Page | 524-528 |
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| Year/Month | 1998/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」Triiodothyronine(T3)を開心術直後に投与することが, 心筋の代謝を活性させることは報告したが1), T3の心毒性がどの程度の高濃度で発現するかは不明である. T3は心毒性発現濃度より, 低濃度で心筋代謝活性の効率を上げることが望ましい. 本研究は, 開心術後モデルを用い心筋代謝に対してT3+Coenzyme Q10(CoQ10)がどの様な影響を及ぼすかについて検討した. 雑種イヌを用い, 60分間の心筋保護液による心停止を行い開心術後状態のモデルを作成した. TC群(n=10)は大動脈遮前よりCoQ10:5mg/kgを, そして大動脈遮断直後よりT3:0.1μg/kg/minを経静脈的に投与し, T3のみを投与したT群(n=8)と何も投与しなかった対照C群(n=10)とで以下の項目について血中T3濃度との関係を比較検討した. 冠状静脈血流量, 心筋酸素摂取量, 心筋乳酸摂取量, 心筋ブドウ糖摂取量, 心筋遊離脂肪酸摂取量, その結果TC群では低濃度の血中T3にて冠静脈血流量・心筋酸素摂取量・心筋乳酸摂取量・心筋ブドウ糖摂取量がピークとなりT3濃度からみた代謝効率は向上していた. また, T群には見られなかった心筋遊離脂肪酸摂取の向上も血中T3濃度に相関して見られた. 以上の結果からCoQ10はT3の心筋代謝活性の効率を上げると考えられた. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | 開心術, 心筋基質摂取量, Triiodothyronine, CoenzymeQ10, 雑種イヌ |
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| English |
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| Title | Effect of Thyroid Hormone and Coenzyme Q10 on the Myocardial Metabolism following Open-Heart Surgery in Mongrel Dogs |
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| Authors | Noriyuki Murai*, Yasushi Katayama*, Takao Imazeki*, Takashi Yamada*, Shigeyoshi Gon*, Hirotsugu Yoshida*, Ikkoku Hata*, Yasuhiro Satou*, Nobuaki Kaki*, Hiroshi Kiyama*, Shiroyuki Nagasawa*, Eiki Sano*, Yoshihito Irie* |
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| Authors(kana) | |
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| Organization | *Department of Cardiovascular and Thoracic Surgery, Koshigaya Hospital, Dokkyo University School of Medicine |
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| Journal | Circulation Control |
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| Volume | 19 |
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| Number | 4 |
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| Page | 524-528 |
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| Year/Month | 1998/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | The effect of triiodothyronine (T3) and coenzyme Q10 (CoQ10) on the myocardial metabolism was studied in mongrel dogs with 60 min of normothermic crystalloid cardioplegic arrest. Animals were divided into three groups : control (n=10), group T (n=8) which received T3 (0.1 μg/kg/min) intravenously after aortic cross-clamping, and group TC (n=10) which received intravenous CoQ10 (5mg/kg) before aonic cross-clamping and intravenous T3 (0.1 μg/kg/min) after aortic cross-clamping. Myocardial oxygen, lactate, glucose and free fatty acid uptake were measured before, immediately after and, 30, 60, and 120 min following the release of aortic cross-clamping. Group T and group TC increased myocardial oxygen, lactate and glucose uptake. Control showed no change in myocardial uptake of oxygen, lactate and glucose. T3 administration produced the increases in coronary sinus flow and myocardial oxygen, lactate and glucose uptake depending on the T3 concentration. Reviewing the changes in the myocardial oxygen, lactate and glucose uptake to T3 concentration, it is clearly shown that the metabolic improvement by CoQ10 is specific to the myocardium and more efficient in the group TC. Myocardial uptake of free fatty acid in group TC is depending on the T3 concentration. Control and group T showed no change in myocardial upyake of free fatty acid. These studies showed that CoQ10 administration makes T3 effect more hyperactive, and increases substrate uptake in low T3 concentration. |
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| Practice | Basic medicine |
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| Keywords | Open heart surgery, Myocardial substrate uptake, Coenzyme Q10, Triiodothyronine, Mongrel dogs |
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