| Japanese |
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| Title | CABG手術における麻酔薬の選択が局所脳内酸素飽和度(rSo2)に及ぼす影響 |
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| Authors | 木下平次郎*, 坂本浩**, 脇坂博士**, 神田知枝*, 森本裕二*, 真弓享久*, 劔物修* |
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| Authors(kana) | |
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| Organization | *北海道大学医学部麻酔学講座, **心臓血管センター北海道大野病院麻酔科 |
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| Journal | 循環制御 |
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| Volume | 19 |
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| Number | 4 |
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| Page | 538-541 |
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| Year/Month | 1998/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」開心術においては, 早期抜管をめざして従来の大量オピオイド投与法に代わり, 少量のオピオイドを投与する麻酔法が広く行われている. 一方, 人工心肺(CPB)を使用する手術では術後脳機能障害の予防は特に重要な問題である. 本研究では冠動脈バイパス術(CABG)を予定された175人において, 従来の大量フェンタニールとミダゾラムを用いた麻酔法を対照群とし, 吸入麻酔薬やプロポフォールとフェンタニール投与量の組み合わせにより患者を7群に分け, 局所脳内酸素飽和度(rSo2)をCPB中とその前後に分けて測定し, 各麻酔法で比較した. 各群のrSo2は対照群と比べ有意な低下はなく, 脳機能の維持において同程度, あるいはそれ以上に安全であるといえた. |
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| Practice | 基礎医学・関連科学 |
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| English |
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| Title | Comparison of Cerebral Regional Oxygen Saturation with Inhaled Anesthetics and Propofol-based Anesthesia during CABG Surgery with Cardiopulmonary Bypass |
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| Subtitle | |
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| Authors | Heijiro Kinoshita*, Hiroshi Sakamoto**, Hiroshi Wakisaka**, Tomoe Kannda*, Yuji Morimoto*, Takahisa Mayumi*, Osamu Kemmotsu* |
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| Authors(kana) | |
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| Organization | *Department of Anesthesiology, Hokkaido University School of Medicine, **Department of Anesthesia, Cardiovascular Center Hokkaido Ohno Hospital |
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| Journal | Circulation Control |
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| Volume | 19 |
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| Number | 4 |
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| Page | 538-541 |
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| Year/Month | 1998/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | Small dose opioid anesthesia has been widely used for early extubation and fast track in cardiac anesthesia. Because patients often have systemic vascular problems, prevention of perioperative cerebral hypoperfusion, especially during cardiopulmonary bypass (CPB) period, is important. Accordingly, we evaluated regional cerebral oxygen saturation (rSo2) in 175 patients undergoing coronary artery bypass graft (CABG) surgery. We compaired changes of rSo2 under small dose of fentanyl anesthesia with isoflurane, sevoflurane or propofol, and high dose fentanyl anesthesia with midazolam or propofol. Patients in each anesthetic group showed the same or slight decreases of cerebral oxygenation during the CPB period. Small dose opioid anesthesia with volatile anesthetics or propofol is as safe as or better than the conventional high dose opioid anesthesia with benzodiazepine or propofol in CABG surgery. |
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| Practice | Basic medicine |
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| Keywords | Cardiopulmonary bypass, CABG, Regional cerebral oxygen saturation, Propofol, Isoflurane, Sevoflurane, Fentanyl |
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