| Japanese |
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| Title | 虚血性心疾患における低用量ドブタミン負荷時の冠血流動態-ドプラーガイドワイヤーによる検討- |
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| Authors | 尾林徹*, 岡本美弘*, 徳永毅*, 飯泉智弘*, 萩元宣彦**, 丹羽明博** |
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| Organization | *取手協同病院循環器内科, **武蔵野赤十字病院循環器科 |
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| Journal | 循環制御 |
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| Volume | 20 |
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| Number | 1 |
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| Page | 74-79 |
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| Year/Month | 1999/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」虚血性心疾患53例, 正常冠動脈7例を対象に, 3〜5μg/kg/minの低用量ドブタミン負荷時の冠動脈内血流速を, ガイドワイヤー型ドプラー血流速計を用いて計測し, ドブタミン負荷時の冠血流動態につき検討した. 心拍数は70bpmが負荷10分後に79bpmとなり, 平均血圧は102mmHgから負荷10分後には106mmHgで一定となった. 冠動脈径は不変, 平均最大流速(APV)は21→31(cm/sec)と上昇し負荷7分で一定となった. 拡張期/収縮期最大流速比(DSVR)は不変であった. 冠血流量は心拍出量の増加分に応じて増した. 各計測値が定常状態に達するまでに7〜8分間を要した. |
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| Practice | 基礎医学・関連科学 |
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| English |
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| Title | Coronary Flow Dynamics during Low-dose Dobutamine Infusion in Patients with Ischemic Heart Disease-Using the Intracoronary Doppler Flow Guide Wire - |
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| Authors | Tohru Obayashi*, Yoshihiro Okamoto*, Takeshi Tokunaga*, Tomohiro Iizumi*, Nobuhiko Hagimoto**, Akihiro Niwa** |
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| Authors(kana) | |
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| Organization | *Division of Cardiology, Toride Kyodo General Hospital, **Department of Cardiology, Musashino Red-cross Hospital |
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| Journal | Circulation Control |
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| Volume | 20 |
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| Number | 1 |
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| Page | 74-79 |
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| Year/Month | 1999/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | We evaluated the intracoronary (＃7 of LAD ; left anterior descending coronary) flow velociry using a doppler-flow-guide-wire during low-dose dobutamine infusion (3 or 5 μg/kg/min) in 60 patients with ischemic heart disease, without significant LAD stenosis. Hemodynamic changes were as follows, heart rate increased from 70 ±9 to 79 ± 14 beats/min, mean blood pressure also increased from 102 ± 13 to 110 ± 18 mmHg, and the APV (average peak velocity) from 21 ±11 to 31 ± 18 cm/sec after seven minutes low-dose dobutamine infusion, while the coronary vesssel diameter and DSVR (intracoronary diastolic systolic peak velocity ratio) were unchanged. There were no differences between hemodynamic variables after seven minutes and ten minutes infusion. These findings suggest that” seven minutes of dobutamine infusion” may be necessary for making a steady state. Therefore, when we perform low-dose dobutamine stress test, the duration of dobutamine infusion is important to the intracoronary-doppler-flow variables (APV, DSVR), especially to coronary flow. |
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| Practice | Basic medicine |
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| Keywords | Low dose dobutamine, APV (average peak velocity) , Intracoronary Doppler flow guide wire, Coronary flow dynamics, IHD (ischemic heart disease) |
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