| English |
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| Title | Chronotropic Effect of Isoproterenol is Reduced in the Female after Continuous Cervical Epidural Blockade Combined with Light General Anesthesia |
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| Authors | Takahisa Mayumi*, Tatsushi Saito*, Itaru Katsuyama*, Takaki Sibano*, Atsunori Kida*, Yuji Morimoto* |
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| Authors(kana) | |
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| Organization | *Department of Anesthesiology and Intensive Care, Hokkaido University School of Medicine |
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| Journal | Circulation Control |
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| Volume | 20 |
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| Number | 2 |
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| Page | 186-191 |
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| Year/Month | 1999/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | 「Abstract」The contribution of cardiac β-adrenoceptor sensitivity secondary to cervical epidural anesthesia induced cardiac sympathectomy has not been confirmed in humans. This study was designed to evaluate whether cardiac sympathectomy induced by continuous cervical epidural anesthesia could modify the sensitivity to the chronotropic effect of isoproterenol in lightly anesthetized female adult patients. 51, ASA physical 1 status and adult female patients who were scheduled for mastectomy under general anesthesia combined with cervical epidural blockade. 10 ml of 2% plain lidocaine was administered every hour through an indwelling epidural catheter placed at C6-C7. Anesthesia was maintained with 60% nitrous oxide in oxygen supplemented by diazepam 5 mg, every one hour. We measured the dose of isoproterenol that increased heart rate by 25 bpm, chronotropic dose of 25, after each epidural injection. We also measured blood concentrations of lidocaine 15 min after each epidural lidocaine administration and plasma epinephrine and norepinephrine levels before the first epidural injection, 30 min after the start of surgery and 90 min after the end of surgery. |
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| Practice | Basic medicine |
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