| Japanese |
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| Title | 揮発性吸入麻酔薬が心筋虚血再灌流障害に及ぼす影響-in vivoウサギモデルにおける検討- |
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| Authors | 丸山久雄*, 吉田和市*, 神田元彦*, 古屋宗孝*, 大澤昭義* |
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| Organization | *神奈川歯科大学麻酔学教室 |
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| Journal | 循環制御 |
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| Volume | 20 |
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| Number | 3 |
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| Page | 288-293 |
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| Year/Month | 1999/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」本研究は, in vivoウサギ心筋虚血再灌流モデルを用い, 循環動態, 虚血域(以下area at risk)及び心筋梗塞サイズ(以下infarct size)を指標にし3つの揮発性吸入麻酔薬が心筋虚血再灌流障害に及ぼす影響を検討した. ウサギ(n=24)を全身麻酔下に開胸し, 左冠状動脈前下行枝を結紮し30分間虚血を行った後, 3時間の再灌流を行った. 実験中は血圧, 心拍数, 心電図を持続的にモニタリングした. 実験群はケタミン/ザイラジン(コントロール群n=6, 35mg・kg-1・h-1および5mg・kg-1・h-1), ハロタン1.0%(H群n=6), セボフルラン2.1%(S群n=6), イソフルラン1.2%(I群n=6)とした. Infarct sizeはテトラゾリウムによる染色で評価した. Infarct sizeはコントロール群が43.72±6.7に文寸し, H群24.85±7.0, S群30.24±4.5, I群41.72±4.7(mean ± SEM)であり, H群とS群において心筋梗塞サイズは有意に減少していた. またH群においてはrate pressure productの有意な低下が認められた. 以上よりウサギ心筋虚血再灌流モデルにおいてハロタン, セボフルランは心筋に対して保護的に作用することが示唆された. また, ハロタンの心筋保護には心筋酸素消費量の減少が関与している可能性が示唆された. |
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| Practice | 基礎医学・関連科学 |
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| English |
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| Title | Effects of Volatile Anesthetics on Myocardial Ischemia/Reperfusion Injury-A Study in in-vivo Rabbit Model- |
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| Authors | Hisao Maruyama*, Kazu-ichi Yoshida*, Munetaka Furuya*, Motohiko Kanda*, Akiyoshi Ohsawa* |
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| Organization | *Department of Anesthesiology, Kanagawa Dental College |
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| Journal | Circulation Control |
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| Volume | 20 |
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| Number | 3 |
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| Page | 288-293 |
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| Year/Month | 1999/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | We evaluated the effects of inhalation anesthetic agents, halothane, sevoflurane, isoflurane on myocardial infarction within a quantified ischemic risk area in rabbit hearts subjected to a regional ischemia -reperfusion injury. In-vivo rabbit hearts (n=24) were received regional ischemia by 30 min. of the left anterior descending artery occlusion and followed by 180 min. of reperfusion under general anesthesia. The anesthetics studied were : ketamin/xylazine (35mg/kg and 5mg/kg respectively, n=6), halothane 1.0% (n=6), sevoflurane 2.0% (n=6), and isoflurane 12% (n=6). The infarct size determined by tetrazolium staining was : 43.72 ± 6.9% in ketamin/xylazine, 24.85 ± 7.0% in halothane, 30.74 ± 4.5% in sevoflurane, and 37.12 ± 5.5% in isoflurane. The infarct size was smaller in the halothane and sevoflurane groups than in the ketamine/xylazine group. It was observed that rate pressure product was decreased in the halothane group. It was suggested that halothane and sevoflurane could protect myocardium against ischemia-reperfusion injury. It was also suggested that cardioprotection by halothane was related to decrease in myocardial oxygen consumption. |
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| Practice | Basic medicine |
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| Keywords | Ischemia-reperfusion injury, Myocardial protection, Halothane, Sevoflurane, Isoflurane |
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