| Japanese |
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| Title | 血中プロポフォール濃度におよぼす硬膜外麻酔の影響 |
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| Subtitle | |
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| Authors | 足立裕史*, 森知久*, 渡辺和彦*, 内橋慶隆*, 佐藤哲雄* |
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| Authors(kana) | |
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| Organization | *防衛医科大学校麻酔学講座 |
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| Journal | 循環制御 |
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| Volume | 20 |
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| Number | 4 |
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| Page | 419-424 |
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| Year/Month | 1999/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」硬膜外麻酔が, プロポフォールを持続的に投与している際の血中濃度に及ぼす影響を検討した. 全身麻酔併用下で硬膜外腔に局所麻酔薬を3回以上投与する症例に対し, 2, 3回目の硬膜外腔局所麻酔薬投与前後で血清プロポフォール濃度を測定した. 測定までに, 20ml・kg-1の晶質液を負荷して硬膜外麻酔による循環動態の変動を回避した. 硬膜外麻酔前後の心拍出量と循環血液量をパルスダイデンシトメトリー法によって測定した. 血清プロポフォール濃度は硬膜外麻酔による有意な影響を受けず, 同一速度で投与することによる一貫した上昇のみを認めた. 心拍出量, 循環血液量にも有意な差は認められなかった. 十分な前負荷を維持しておくことにより, プロポフォール濃度, 心拍出量, 循環血液量は硬膜外麻酔の影響をほとんど受けないと考えられた. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | |
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| English |
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| Title | The Effect of Epidural Anesthesia on The Serum Concentration of Propofol. |
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| Subtitle | |
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| Authors | Yushi Adachi*, Tomohisa Mori*, Kazuhiko Watanabe*, Yoshitaka Uchihashi*, Tetsuo Satoh* |
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| Authors(kana) | |
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| Organization | *Department of Anesthesiology, National Defense Medical College |
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| Journal | Circulation Control |
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| Volume | 20 |
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| Number | 4 |
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| Page | 419-424 |
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| Year/Month | 1999/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | The effect of epidural anesthesia on the serum concentration of continuously infused propofol during general anesthesia was investigated. Epidural anesthesia was performed more than two times during surgery, and the changes of serum concentrations of propofol were measured at second and third epidural administrations of local anesthetics. Before measurements, 20 ml・kg-1 of acetate Ringer solution were infused to the patient to avoid an qdverse cardiovascular depression by epidural anesthesia. Cardiac outputs and circulating blood volumes of the patient were also evaluated by pulse dye-densitometory using DDG-2001 (Nihon Kohden Corp. ). The serum concentrations of propofol were not affected by epidural anesthesia and showed consistent increase which might be derived from constant rate infusion of propofol. Cardiac outputs and circulating blood volumes also showed no significant difference between before and after epidural administration of local anesthetics. When sufficient pre-load is acquired for a patient against epidural anesthesia, cardiac outputs, circulating blood volumes and concentrations of propofol are not significantly affected by epidural anesthesia. |
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| Practice | Basic medicine |
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| Keywords | Propofol, Epidural anesthesia, Dye-densitometory |
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