| English |
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| Title | Comparism of Hemodynamic and Catecholamine Responses between Propofol and Thiamylal Used in a Rapid Sequence Induction |
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| Subtitle | |
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| Authors | Tetsuya Hara*, Makoto Fukusaki*, Toshiaki Nakamura*, Sadayo Niiya*, Koji Sumikawa** |
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| Authors(kana) | |
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| Organization | *Department of Anesthesiology,Nagasaki Rosai Hospital, **Department of Anesthesiology,Nagasaki University School of Medicine |
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| Journal | Circulation Control |
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| Volume | 21 |
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| Number | 1 |
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| Page | 32-36 |
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| Year/Month | 2000/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | Authors evaluated hemodynamic and catecholamine responses during rapid sequence induction with propofol compared to those with thiamylal without any influences of other anesthetic agent. After institutional approval and informed consent, 20 ASA physical status I and II patients were randomly divided into two groups. Anesthesia was induced with either thiamylal, 5 mg・kg-1, (n=10) or propofol, 2 mg・kg-1, (n=10). Trachea was intubated under succinylcholine, 1.5 mg・kg-1, min after induction followed by artificial ventilation with pure oxygen until the end of the study. Hemodynamic parameters and plasma catecholamine concentrations were measured as appropriate during the study period. Systolic blood pressure, heart rate and rate pressure product showed significant increases after intubation in both groups (p<0.01). However, these increases were greater (p<0.05) in thiamylal group compared to propofol group. The trend of ST-segment in electrocardiogram showed no ischemic change in either group. Plasma epinephrine showed no significant change in either group. Plasma norepinephrine showed a significant increase after intubation in thiamylal group (p<0.05) but not in propofol group. Three patients in thiamylal group had arrhythmias after intubation. The results suggest that propofol would be more useful for rapid sequence induction compared with thiamylal regarding hemodynamic and catecholamine responses in normotensive patients. |
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| Practice | Basic medicine |
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| Keywords | Catecholamines, Hemodynamics, Propofol, Rapid sequence induction |
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