| Japanese |
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| Title | 酸素消費量モニタを利用した全人工心臓の流量制御法の開発 |
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| Subtitle | 原著 |
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| Authors | 中村真人*, 本間章彦***, 高谷節雄*, 大内克洋*, 坂本徹**, 上所邦広***, 巽英介***, 妙中義之***, 増澤徹**** |
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| Authors(kana) | |
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| Organization | *東京医科歯科大学生体材料工学研究所, **東京医科歯科大学医学部, ***国立循環器病センター研究所, ****茨城大学工学部 |
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| Journal | 循環制御 |
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| Volume | 21 |
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| Number | 4 |
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| Page | 419-426 |
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| Year/Month | 2000/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 全人工心臓(TAH)では, 光センサーを組み込むことで, Fick法により, 酸素消費量のリアルタイムモニタリングが可能になる. 生体の酸素需要, 血流要求に合わせたTAHの制御を行うために, 酸素消費量を利用することを目的に, 酸素消費量と心拍出量の関係と, それらの反応速度を, 正常動物を用いて検討した. 運動時の両者は線形相関とみなせ, その回帰式の傾きが制御に有効と考えられた. また, ステップ応答による反応速度の検討でも, 酸素消費量は生体の要求変化を迅速に反映することが判明した. この方法により生体に適した, しかも迅速な制御が可能であることが示された. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | Total artificial heart, Physiological control, Oxygen consumption, Optical sensor, Cardiac output |
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| English |
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| Title | Development of Control Method for Total Artificial Heart Using Continuous Oxygen Consumption Monitoring |
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| Authors | Makoto Nakamura*, Akihiko Homma**, Setsuo Takatani*, Katsuhiro Ouchi*, Toru Sakamoto*, Kunihiro Uesho*, Eisuke Tatsumi**, Yoshiyuki Taenaka***, Toru Masuzawa*** |
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| Authors(kana) | |
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| Organization | *Tokyo Medical and Dental University, **National Cardiovascular Center, ***Ibaraki University |
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| Journal | Circulation Control |
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| Volume | 21 |
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| Number | 4 |
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| Page | 419-426 |
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| Year/Month | 2000/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | Oxygen consumption is a parameter which directly reflects oxygen metabolism and the needs of the blood flow. It can be monitored in real time, using a TAH system equipped with optical sensors and employing Fick's principle. For controlling the output of a total artificial heart (TAH), we investigated the relationship between oxygen consumption and cardiac output (CO), along with their response speed, in normal animals. Linear relationships were found between oxygen consumption and CO, with approximately similar regression slopes, in each exercise test. Such slopes were also recognized in the observation for a few days. These slopes are considered useful for controlling TAH output to meet changes in the demand of the recipient. The response speed of oxygen consumption was also investigated by comparing it with that of CO in step responses to exercise changes. Oxygen consumption response was found to be as immediate as that in CO. Our results indicate that oxygen consumption is a suitable monitoring parameter for controlling TAH output physiologically, in both response degree and response speed. Using this variable for monitoring, TAH physiological control can be realized, providing the recipient with a more reliable and effective device. |
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| Practice | Basic medicine |
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| Keywords | Total artificial heart, Physiological control, Oxygen consumption, Optical sensor, Cardiac output |
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