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| Title | A Negligible Amount of Plasma Lactate Clearance by Large-pore Continuous Venovenous Hemodiafiltration in Septic Renal Failure. |
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| Subtitle | Original article |
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| Authors | Yoshiaki Terao*, Motohiro Sekino*, Koji Yamaguchi**, Koji Sumikawa* |
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| Authors(kana) | |
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| Organization | *Department of Anesthesiology, Nagasaki University School of Medicine, **Intensive Care Unit, Nagasaki University Hospital |
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| Journal | Circulation Control |
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| Volume | 22 |
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| Number | 2 |
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| Page | 120-124 |
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| Year/Month | 2001/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | The present study was carried out to determine if plasma lactate could be removed by large-pore continuous venovenous hemodiafiltration (LP-CVVHDF) in 10 patients with septic renal failure. LP-CVVHDF was performed using a large-pore polyacrylonitrile hemofilter (cut off point: 55-65kD). The blood flow rate through the extracorporeal system was 80ml/min with a bicarbonate dialysis fluid rate of 500ml/hr. The ultrafiltration rate was 500ml/hr and a bicarbonate replacement solution was administered at a rate of 400-500ml/hr in a postfilter fashion. Simultaneous samples of arterial, and filter inlet and outlet blood and ultradiafiltrate were collected before starting CVVHDF, and 4hr, 12hr and 24hr after starting CVVHDF. Plasma lactate clearance (ml/min) with LP-CVVHDF was 15.9±0.4 at 4hr, 16.1±0.3 at 12hr and 16.5±0.4 at 24hr. There were no significant differences in the plasma lactate concentration among the time point. Lactate-sieving coefficient by LP-CVVHDF was 0.95±0.08 at 4hr, 0.98±0.09 at 12hr and 0.99 ± 0.07 at 24hr. The results show that plasma lactate clearance by LP-CVVHDF is much smaller than endogenous plasma lactate clearance in septic renal failure. |
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| Practice | Basic medicine |
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| Keywords | lactate, tissue oxygenation, renal failure, hemodiafiltration, sepsis |
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