| English |
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| Title | Significance of Systemic Inflammatory Response Syndrome After Hepatectomy |
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| Subtitle | Original article |
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| Authors | Yuji Morimoto, Maid Aoyama, Satoshi Gando, Shigeaki Kobayashi, Toshiteru Ishitani, Satoshi Nanzaki, Shigeyuki Sasaki, Osamu Kemmotsu |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology and Critical Care Medicine, Hokkaido Univ Grad Sch of Med. |
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| Journal | Circulation Control |
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| Volume | 22 |
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| Number | 3 |
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| Page | 215-219 |
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| Year/Month | 2001/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | We evaluated whether systemic inflammatory response syndrome (SIRS) after hepatectomy should be a sign of poor outcome and what peri-operative factors were related to SIRS after hepatectomy. Sixty patients, who had elective hepatectomy and admitted to the ICU after tracheal extubation were divided into two groups according to whether they were diagnosed as SIRS within 12 hours after ICU admission or not. Organ dysfunction (central nervous system, cardiovascular system, pulmonary system, hepatic system, renal system, the intestine, or the hematology) was evaluated in the next morning, on the 3rd and 7th day after surgery and compared between the two groups. We compared the peri-operative factors including demographic data, anesthetic and surgical data, and ICU data between the two groups. Thirtyone patients were diagnosed as SIRS. In the next morning, 27 out of the 31 SIRS patients and 26 out of the 29 non-SIRS patients showed liver dysfunction. Three days after surgery, 25 SIRS patients and 25 non-SIRS patients still showed liver dysfunction while only two SIRS patients had liver dysfunction 7 days after surgery. The incidence of liver dysfunction was not significantly different between the groups. Dysfunction of other organs was not observed in both groups. All the patients were alive 28 days after surgery. A significantly lower incidence of preoperative liver cirrhosis was found in the SIRS patients. There were no significant differences in other perioperative factors between the two groups. In conclusion, SIRS in the early phase of post-hepatectomy may not be a sign of poor outcome. Accordingly, it has little clinical significance and may rather be only a physiological response to hepatectomy. Preoperative liver cirrhosis may prevent such a response after hepatectomy. |
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| Practice | Basic medicine |
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| Keywords | Systemic inflammatory response syndrome, Hepatectomy, Liver cirrhosis |
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