| Japanese |
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| Title | 体外キャリブレイションを要しないコンダクタンス心室容積計測システムの開発 |
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| Subtitle | 原著 |
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| Authors | 上村和紀*, 杉町勝*, 宍戸稔聡*, 川田徹*, 稲垣正司*, 鄭燦***, 佐藤隆幸**, 砂川賢二* |
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| Authors(kana) | |
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| Organization | *国立循環器病センター研究所循環動態機能部, **高知医科大学第二生理学, ***日本宇宙フォーラム |
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| Journal | 循環制御 |
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| Volume | 23 |
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| Number | 3 |
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| Page | 269-277 |
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| Year/Month | 2002/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | コンダクタンスカテーテルによる心室容積計測法において, 血液電気伝導度とパラレルコンダクタンスに対する体外補正を要しないシステムを開発した. 血液電気伝導度は, 電流の伝導範囲が心室内血液にのみ収束するよう近接して配置したカテーテル電極で計測し, パラレルコンダクタンスは二重周波数法にて推定した. ウサギおよびラットにおいて, このシステムで推定された血液電気伝導度, パラレルコンダクタンスは従来法にて計測された値と良好に一致し, 得られた心室容積も従来法とほぼ一致した. 開発されたシステムは体外補正作業を要さずコンダクタンス法を簡易化し, 小動物において心室容積を計測する上で有用と考えられた. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | Conductance catheter volumety, Blood conductivity, Parallel conductance |
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| English |
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| Title | Conductance Volumetry without Ex-vivo Calibrations for Blood Conductivity and Parallel Conductance in Small Experimental animals |
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| Subtitle | |
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| Authors | Kazunori Uemura*, Masaru Sugimachi*, Toshiaki Shishido*, Toru Kawada*, Masashi Inagaki*, Can Zheng***, Takayuki Sato**, Kenji Sunagawa* |
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| Authors(kana) | |
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| Organization | *Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, **Second Department of Physiology, Kochi Medical School, ***Japan Space Forum |
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| Journal | Circulation Control |
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| Volume | 23 |
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| Number | 3 |
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| Page | 269-277 |
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| Year/Month | 2002/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | The conductance volumetry requires ex-vivo calibration with blood conductivity and parallel conductance. It is impractical to repeat blood sampling and saline infusion frequently for these calibrations in small animals. To overcome these limitations, we developed a conductanece system with no need of ex-vivo calibrations for these quantities. On a conventional catheter, we added extra electrodes to estimate blood conductivity. These electrodes were placed closely enough so that sample volume was confined within the ventricular blood pool. We estimated parallel conductance by dual-frequency excitation. In 18 rabbits, blood conductivity thus estimated agreed well with that measured by blood sampling （1.20% error）. Parallel conductance estimated by the dualfrequency method also agreed well with that estimated by saline injections（6.0% error）, Estimated ventricular volume by our method agreed well with that by the conventional method （Vest＝ 0.93 Vconv＋0.01, R2 ＝ 0.86, 14.7% error）. In 8 rats, reasonable accuracy of blood conductivity （3.5% error）, parallel conductance （6.0% error）, and ventncular volume （Vest＝1.1 Vconv-13.2, R2＝0.93, 21% error） were also obtained The developed system, that does not require ex-vivo calibration, drastically simplifies experimental protocols, thereby makes it a very attractive tool in measuring ventricular volume in small experimental animals. |
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| Practice | Basic medicine |
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| Keywords | Conductance catheter volumety, Blood conductivity, Parallel conductance |
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