| Japanese |
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| Title | オフポンプ冠動脈バイパス術におけるオルプリノンおよびミルリノンの有用性 |
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| Subtitle | 原著 |
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| Authors | 謝慶一, 岩田正人, 本図淑子, 森匡世, 米本紀子, 北口勝康, 平井勝治, 古家仁 |
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| Organization | 奈良県立医科大学麻酔科学教室 |
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| Journal | 循環制御 |
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| Volume | 23 |
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| Number | 3 |
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| Page | 284-288 |
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| Year/Month | 2002/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | オフポンプ冠動脈バイパス術患者24症例に対するオルプリノンおよびミルリノンの有用性を検討した. オルプリノン（12症例）またはミルリノン（12症例）を麻酔導入直後より持続静脈内投与（0.2および0.4mcg・kg-1・min-1）した. いずれも心拍数および心拍出量は導入後に比べ吻合時, 吻合後, 閉胸後で有意に高値で, 体血管抵抗は低値であった（P＜0.05）. 従って, オフポンプ冠動脈バイパス術に対するオルプリノンおよびミルリノンの投与は心拍出量を増加させ, 冠動脈吻合時および閉胸後の平均肺動脈圧, 右心房圧, 肺動脈楔入圧の有意な上昇を血圧の低下を来すことなく抑えることが可能であり, 有用な投与法であった. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | Olprinone, Milrinone, Off-pump CABG |
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| English |
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| Title | Effects of Olprinone and Milrinone in Patients Undergoing Off-pump Coronary Artery Bypass Grafting |
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| Authors | Keiichi Sha, Masato Iwata, Yoshiko Motozu, Masayo Mori, Noriko Yonemoto, Katsuyasu Kitaguchi, Katsuji Hirai, Hitoshi Furuya |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology, Nara Medical University |
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| Journal | Circulation Control |
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| Volume | 23 |
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| Number | 3 |
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| Page | 284-288 |
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| Year/Month | 2002/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | We evaluated retrospectively the effectiveness of olprinone and milrinone in 24 patients （olprinone group： 12 patients, milrinone group： 12 patients） undergoing off-pump coronary artery bypass grafting（ CABG）. Olprinone and milrinone were intravenously administered at the rate of 0.2 and 0.4 mcg ・kg-1・min-1 after induction of anesthesia. The hemodynamic variables and concomitant drugs were compared in both groups, Hemodynamics were measured before, during and after coronary artery anastomosis, and after the chest closure. Cathecholamine and vasodilator were used to maintain to mean arterial pressure （＞60mmHg） and cardiac index（＞3.0L・min-1・m-2). Systolic bood pressure, mean pulmonary artery pressure, right atrial pressure, pulmonary artery wedge pressure and pulmonary vascular resistance showed no significant changes. Heart rate and cardiac output were significantly higher during and after anastomosis, and after chest closure than before anastomosis in both groups. Systemic vascular resistance was significantly lower during and after anastomosis, and after chest closure than before anastomosis in both groups. Infusion of olprinone and milrinone prevents the elevations of mean pulmonary artery pressure, right atrial pressure and pulmonary artery wedge pressure without the reduction of systolic bood pressure at coronary artery anastomosis and after the chest closure on off-pump CABG. In conclusion, in the cases undergoing off-pump CABG, infusion of olprinone and milrinone from the end of the induction of anesthesia was recommended. |
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| Practice | Basic medicine |
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| Keywords | Olprinone, Milrinone, Off-pump CABG |
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