| Japanese |
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| Title | 局所麻酔薬ブピバカインのR（＋）体, ラセミ体およびS（−）体の心機能への影響 |
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| Subtitle | 原著 |
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| Authors | 寺井志織*, 瀬川文里*, 馬越史歩**, 田村隆**, 西堀崇子*, 廣谷芳彦*, 田中一彦* |
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| Authors(kana) | |
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| Organization | *大阪薬科大学臨床薬剤学教室, **丸石製薬（株）研究開発本部 |
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| Journal | 循環制御 |
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| Volume | 23 |
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| Number | 4 |
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| Page | 404-409 |
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| Year/Month | 2002/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | ラット摘出心臓標本を用い, ブピバカインのR（＋）体, ラセミ体およびS（−）体の投与濃度と心機能との関係について検討した. 各薬物において, 10〜35μg/mlの濃度で, 心拍数および心拍出量がコントロールの約40％に低下したが, 1回拍出量および左心室圧に有意な低下が認められなかった. このことから, ブピバカインは, 著明に刺激伝導系を抑制すると考えられた. また, 心拍出量は35μg/mlで, R（＋）体, ラセミ体, S（−）体でそれぞれ, 約20％, 30％, 40％まで抑制され, 心機能抑制作用はR（＋）体が最も強く, 次にラセミ体, S（−）体となり, S（−）体が最も心機能抑制作用が少なかった. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | Bupivacaine, Stereoselectivity, Cardiac function, Heart, Rat |
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| English |
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| Title | Stereoselective Effects of Local Anesthetic, R（＋）, racemic, and S（-）forms of Bupivacaine, on Cardiac function in Isolated Rat Hearts |
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| Subtitle | |
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| Authors | Shiori Terai*, Mori Segawa*, Shiho Bakoshi**, Takashi Tamura**, Takako Nishihori*, Yoshihiko Hirotani*, Kazuhiko Tanaka* |
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| Authors(kana) | |
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| Organization | *Department of Clinical Phamiacy and Clinical Pharmacokinetics, Osaka University of Pharmaceutical Sciences, **Central Research Laboratory, Maruishi Pharmaceutical Co.,Ltd. |
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| Journal | Circulation Control |
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| Volume | 23 |
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| Number | 4 |
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| Page | 404-409 |
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| Year/Month | 2002/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | Using isolated rat hearts, the relationship between the concentrations of R （＋） , racemic, and S （-） forms of bupivacaine and cardiac function was investigated. At concentrations of 10〜35μg/ml, all compounds decreased heart rate and cardiac output to about 40％ of those in the control, but there was no significant decreases in stroke volume and left ventricular pressure. Cardiac output was decreased to about 20％, 30％, and 40％ at 35μg/ml of R （＋） , racemic, and S （-） forms, respectively. These finding suggest that bupivacaine severely inhibits the cardiac conducting system. And S （-） forms showed the lowest inhibitory effect on cardiac function. |
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| Practice | Basic medicine |
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| Keywords | Bupivacaine, Stereoselectivity, Cardiac function, Heart, Rat |
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