| English |
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| Title | Hemodynamic and catecholamine responses during rapid sequence induction with propofol in hypertensive patients. |
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| Subtitle | |
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| Authors | Toshiaki Nakamura*, Makoto Fukusaki*, Masahiko Miyako*, Sadayo Niiya*, Koji Sumikawa** |
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| Authors(kana) | |
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| Organization | *Department of Anesthesia, Nagasaki Rosai Hospital, **Department of Anesthesiology, Nagasaki University School of Medicine |
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| Journal | Circulation Control |
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| Volume | 23 |
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| Number | 4 |
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| Page | 420-424 |
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| Year/Month | 2002/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | Purpose：This prospective controlled study evaluated hemodynamic and catecholamine responses during rapid sequence induction （RSI） with propofol in hypertensive patients. Methods：Twenty patients for elective surgery were divided into two groups. Group N （n＝10） consisted of normotensive patients. Group H（n＝10）consisted of hypertensive patients controlled with Ca2+ antagonists. RSI was performed using propofol and suxamethonium after precurarization with vecuronium. Measurements included systolic blood pressure （SBP）, heart rate （HR） and plasma concentrations of epinephrine （E） and norepinephrine （NE）. They were measured before precurarization as baseline （TB）, immediately before intubation, i.e., pre-intubation （PREI）, immediately after intubation（T0）, and 1 min （T1）, 2 min （T2） and 3 min （T3） after intubation. Results ： In group N, SBP significantly decreased at PREI and increased at T0 compared with TB, while heart rate （HR） significantly increased at T0. In group H, SBP at TB was significantly higher than that in group N （166±7 vs 141±3 mmHg）. SBP in group H significantly decreased at PREI, but returned to the baseline level at T0 showing no significant difference from TB thereafter. HR in group H showed no significant change throughout the time course. Plasma concentrations of epinephrine （E） and norepinephrine （NE） showed no change in either group, whereas the plasma concentration of NE in group H was significantly higher than that in group N at TB, T1 and T3. Conclusion ： We conclude that hypertensive patients show smaller increases in blood pressure and heart rate after endotracheal intubation than normotensive patients during rapid sequence induction with prepofol. |
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| Practice | Basic medicine |
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| Keywords | Propofol, Rapid sequence induction, Hypertension |
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