| Japanese |
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| Title | 血行動態波形情報の解析による大動脈粥状硬化早期病変の検出 |
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| Subtitle | 原著 |
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| Authors | 宮下洋*, **, 勝田新一郎***, 清水強***, 挾間章博***, 島田和幸**, 矢田俊彦* |
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| Authors(kana) | |
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| Organization | *自治医科大学生理学講座統合生理学部門, **自治医科大学内科学講座循環器内科学部門, ***福島県立医科大学医学部生理学第1講座 |
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| Journal | 循環制御 |
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| Volume | 24 |
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| Number | 4 |
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| Page | 360-370 |
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| Year/Month | 2003/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」大動脈入力インピーダンス(Zin)解析により定量化した動脈壁特性による大動脈の粥状硬化病変早期検出の可能性を, 遺伝性高コレステロールウサギを用いて検討した. 不規則ペーシング下の上行大動脈圧・血流波形より得られた高分解能のZinは, 低周波領域の特定周波数に対しては顕著な変化を呈し, 特性インピーダンスは軽度低下していた. Zinの変化が特定の周波数に限られることは, 高分解能Zinの有効性を示唆する. 大動脈の早期病変が低周波のZinに反映されることは, 特性インピーダンスや動脈波形解析が高周波での評価を必要とするのと対照的に, 本評価法が臨床検査レベルの血圧・血流計測精度においても有効な可能性を示す. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | Aortic input impedance, Atherosclerosis, Hyperlipidemia, Aortic pressure, Aortic flow |
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| English |
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| Title | Potential of Hemodynamic Waveform Analysis to Detect Early-Stage Atherosclerotic Lesions of the Aorta |
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| Authors | Hiroshi Miyashita*, **, Shin-ichiro Katsuda***, Tsuyoshi Shimizu***, Akihiro Hazama***, Kazuyuki Shimada**, Toshihiko Yada* |
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| Authors(kana) | |
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| Organization | *Division of Integrative Physiology, Department of Physiology, Jichi Medical School, **Division of Cardiology, Department of Internal Medicine, Jichi Medical School, ***Department of Physiology, Fukushima Medical University School of Medicine |
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| Journal | Circulation Control |
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| Volume | 24 |
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| Number | 4 |
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| Page | 360-370 |
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| Year/Month | 2003/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | Alterations in arterial properties detected by pulse wave velocity and pulse wave analyses in patients with hypercholesterolemia are controversial. Therefore, we used an animal model of atherosclerosis to test the potential of arterial mechanical properties indexed by aortic input impedance(Zin)as markers for early detection of atheromatous lesions in the aorta. In 12-month-old anesthetized Kurosawa and Kusanagi-Hypercholesterolemic Rabbits(KHC;n=15), pressure and flow were measured at the ascending aorta during sinus rhythm and random pacing. We confirmed histologically in previous studies that earlystage atheromas developed in the aorta by this age. Age-matched Japanese White rabbits(JW;n=13)had no overt atheroma. High-resolution Zin derived from random beating data was characterized by a lower ratio of the first local maximum to minimum /Zin/(1.36 ± 0.26 vs. 2.08 ± 0.33;p<10-5)accompanied by more delayed phases over a range between 6 and 8 Hz(-0.35 ± 0.21 vs. -0.05 ± 0.15 radian;p=0.0002);and a lower characteristic impedance(2.30 ± 0.67 vs. 2.92 ± 0.59 mmHg・s・kg BW/ml;p=0.016)in KHC than in JW rabbits. We concluded that frequencyspecific changes in Zin are sensitive hemodynamic markers that can detect early-stage atheromatous lesions in the aorta. High-resolution Zin analysis is essential and useful for detecting such frequencydependent findings. |
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| Practice | Basic medicine |
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| Keywords | Aortic input impedance, Atherosclerosis, Hyperlipidemia, Aortic pressure, Aortic flow |
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