| English |
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| Title | The effect of dexmedetomidine on transient focal cerebral ischemia in rats |
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| Subtitle | |
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| Authors | Hiroshi Kimotsuki, Hirotsugu Okamoto, Akiko Ozawa, Sumio Hoka |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology, Kitasato University School of Medicine |
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| Journal | Circulation Control |
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| Volume | 25 |
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| Number | 1 |
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| Page | 50-55 |
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| Year/Month | 2004/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | To examine the possibility that the dexmedetomidine-induced cerebral vasoconstriction deteriorates ischemic brain damage, we administered dexmedetomidine during transient focal cerebral ischemia in rats. Rats received intravenous infusions of dexmedetomidine at 0.1μg・kg-1・min-1, and 1μg・kg-1・min-1 during cerebral ischemia induced by the occlusion of the middle cerebral artery with a nylon suture. Further, 5mg・kg-1 of yohimbine combined with dexmedetomidine were also given during the cerebral ischemia. Cerebral infarction was detected in rats receiving infusions of dexmedetomidine at 0.1μg・kg-1・min-1 and 1μg・kg-1・min-1. Cerebral infarct volume was significantly larger in rats receiving dexmedetomidine infusion at 1μg・kg-1・min-1 than that of rats receiving at 0.1μg・kg-1・min-1. Treatment with yohimbine significantly decreased the dexmedetomidine-induced infarct volume by 84%. Therefore, it is suggested that the infusion of highdose dexmedetomidine aggravates ischemic brain damage following focal cerebral ischemia in rats via the activation of alpha-2 adrenoceptor. |
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| Practice | Basic medicine |
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| Keywords | cerebral blood flow, cerebral infarction, cerebral ischemia |
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