| Japanese |
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| Title | 虚血再灌流不整脈に及ぼすエダラボンの影響について |
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| Subtitle | 原著 |
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| Authors | 高見真代, 浦嶋和也, 西堀崇子, 廣谷芳彦, 田中一彦 |
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| Authors(kana) | |
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| Organization | 大阪薬科大学臨床薬剤学教室 |
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| Journal | 循環制御 |
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| Volume | 25 |
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| Number | 3 |
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| Page | 261-266 |
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| Year/Month | 2004/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」エダラボンのラット摘出心における虚血再灌流不整脈に対する抑制作用の有無を検討した. 心摘出後, ランゲンドルフ法による灌流を開始し, 10, 25, 50, 75, 100, 150μMのエダラボンを溶解した灌流液で10分間灌流後, 11分間の虚血を行い, 3分間の再灌流を行った. 冠灌流量, 心拍数に対するエダラボンの影響は認められず, 心室細動(ventricular fibrillation：VF)発生率においてはエダラボン25, 75, 100μMでcontrol群に比べ有意に減少した. しかし, 各濃度間の有意差は認められなかった. Sustained VF発生率は, control群の92%に対し, エダラボン25μMで50%と有意に減少した. エダラボンはラット摘出心の虚血再灌流時の不整脈に対し抑制作用を有することが示唆された. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | エダラボン, 虚血, 再灌流, 不整脈, 活性酸素, edaravone, ischemia, reperfusion, arrhythmia, free radical |
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| English |
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| Title | Effects of Edaravone on Reperfusion-Induced Arrhythmias in the Isolated Rat Heart |
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| Authors | Masayo Takami, Kazuya Urashlma, Takako Nishihori, Yoshihiko Hirotani, Kazuhiko Tanaka |
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| Authors(kana) | |
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| Organization | Department of Clinical Pharmacy and Clinical Pharmacokinetics, Osaka University of Pharmaceutical Sciences |
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| Journal | Circulation Control |
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| Volume | 25 |
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| Number | 3 |
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| Page | 261-266 |
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| Year/Month | 2004/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | The effects of edaravone on reperfusion-induced ventricular arrhythmias in the isolated perfused rat heart were investigated. Using Langendorff perfusionsystem, each isolated rat heart was perfused with Krebs-Henseleit buffer, containing various concentrations of edaravone(0, 10, 25, 50, 75, 100, 150μM)for 10 minutes. After that, each heart was subjected to regional ischemia(11min)and reperfusion(3min). The result showed that edaravone had no significant effect on coronary flow and heart rate at any time during the experiment. At 25, 75, 100μM of edaravone, the incidence of reperfusioninduced ventricular fibrillation(VF)was significantly reduced from the control value(p<0.05). At 25μM of edaravone, the incidence of sustained VF was significantly reduced from 92% to 50%(p<0.05). Edaravone is suggested to have a protective effect against reperfusion-induced arrhythmias. |
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| Practice | Basic medicine |
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| Keywords | edaravone, ischemia, reperfusion, arrhythmia, free radical |
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