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| Title | Migration of neutrophils elicited by leukotriene B4 is inhibited by fasudil, a Rho-kinase inhibitor, in the microvasculature of hamster cheek pouch |
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| Authors | Akiko Ozawa, Yoshihiro Nara, Kimotsuki Hiroshi, Eri Nakahara, Hirotsugu Okamoto, Sumio Hoka |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology, Kitasato University School of Medicine |
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| Journal | Circulation Control |
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| Volume | 25 |
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| Number | 3 |
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| Page | 267-271 |
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| Year/Month | 2004/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | This study was designed to investigate possible effects of a Rho-kinase inhibitor, fasudil, on migration of neutrophils induced by leukotriene B4. The neutrophil behavior was observed in the microvasculature of hamster cheek pouch using a trans-illumination microscope. Superfusion of lekotrience B4 caused an increase in the number of neutrophils adhering the endothelium and migrating through the endothelium outside the venules. The migration induced by lekotrience B4 was significantly attenuated in hamsters receiving intravenous infusion of 10 and 30mg/kg of fasudil prior to the leukotriene B4 superfusion. These results suggest that inhibition of Rho-kinase by fasudil produces an inhibition of neutrophil migration and represents a new therapeutic strategy for neutrophil-mediated tissue damage. |
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| Practice | Basic medicine |
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| Keywords | |
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