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| Title | The effect of α2-adrenergic receptor agonist, dexmedetomidine, on tetrodotoxin resistant Na+ currents in srnall-sized dorsal root ganglion neurons |
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| Subtitle | 原著 |
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| Authors | Miyuki Maruyama, Hirotsugu Okamoto, Takaaki Nakano, Hiroshi Kimotsuki, Sumio Hoka |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology, Kitasato University School of Medicine
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| Journal | Circulation Control |
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| Volume | 26 |
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| Number | 1 |
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| Page | 24-28 |
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| Year/Month | 2005/3 |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | We examined the effects of α2-adrenergic agonist, dexmedetomidine(DEX), on tetrodotoxin-resistant(TTX-r) Na+ currents using small-sized dorsal root ganglion(DRG) cells of the rats. Whole cell patchclamp configuration was used. After control Na+ current was recorded. DEX was added to the extracellular solution. Yohimbine and prazosin were used to differentiate the contribution of α2-adrenergic receptor from that of α1-adrenergic receptor. The peak TTX-r Na+ currents were significantly and dose dependently inhibited by DEX(p<0.05). Yohimbine attenuated the suppressive effects of DEX on TTX-r Na+ currents, while prazosin did not alter the effects of DEX. Thus, DEX inhibited TTX-r Na+ currents by way of α2-adrenergic receptors but not aladrenerglc receptors. Therefore, it is suggested that DEX has an inhibitory effect on TTX-r Na+ channels through α2-adrenergic receptors. |
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| Practice | Basic medicine |
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| Keywords | tetrodotoxin-resistant sodium current, dorsal root ganglion neuron, dexmedetomldine, α2-adrenergic receptor, α1-adrenergic receptor |
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