English |
Title | The effect of ƒ¿2-adrenergic receptor agonist, dexmedetomidine, on tetrodotoxin resistant Na+ currents in srnall-sized dorsal root ganglion neurons |
Subtitle | Œ´’˜ |
Authors | Miyuki Maruyama, Hirotsugu Okamoto, Takaaki Nakano, Hiroshi Kimotsuki, Sumio Hoka |
Authors(kana) | |
Organization | Department of Anesthesiology, Kitasato University School of Medicine
|
Journal | Circulation Control |
Volume | 26 |
Number | 1 |
Page | 24-28 |
Year/Month | 2005/3 |
Article | Original article |
Publisher | Japan Society of Circulation Control |
Abstract | We examined the effects of ƒ¿2-adrenergic agonist, dexmedetomidine(DEX), on tetrodotoxin-resistant(TTX-r) Na+ currents using small-sized dorsal root ganglion(DRG) cells of the rats. Whole cell patchclamp configuration was used. After control Na+ current was recorded. DEX was added to the extracellular solution. Yohimbine and prazosin were used to differentiate the contribution of ƒ¿2-adrenergic receptor from that of ƒ¿1-adrenergic receptor. The peak TTX-r Na+ currents were significantly and dose dependently inhibited by DEX(p<0.05). Yohimbine attenuated the suppressive effects of DEX on TTX-r Na+ currents, while prazosin did not alter the effects of DEX. Thus, DEX inhibited TTX-r Na+ currents by way of ƒ¿2-adrenergic receptors but not aladrenerglc receptors. Therefore, it is suggested that DEX has an inhibitory effect on TTX-r Na+ channels through ƒ¿2-adrenergic receptors. |
Practice | Basic medicine |
Keywords | tetrodotoxin-resistant sodium current, dorsal root ganglion neuron, dexmedetomldine, ƒ¿2-adrenergic receptor, ƒ¿1-adrenergic receptor |