English
TitleThe effect of ƒ¿2-adrenergic receptor agonist, dexmedetomidine, on tetrodotoxin resistant Na+ currents in srnall-sized dorsal root ganglion neurons
SubtitleŒ´’˜
AuthorsMiyuki Maruyama, Hirotsugu Okamoto, Takaaki Nakano, Hiroshi Kimotsuki, Sumio Hoka
Authors(kana)
OrganizationDepartment of Anesthesiology, Kitasato University School of Medicine
JournalCirculation Control
Volume26
Number1
Page24-28
Year/Month2005/3
ArticleOriginal article
PublisherJapan Society of Circulation Control
AbstractWe examined the effects of ƒ¿2-adrenergic agonist, dexmedetomidine(DEX), on tetrodotoxin-resistant(TTX-r) Na+ currents using small-sized dorsal root ganglion(DRG) cells of the rats. Whole cell patchclamp configuration was used. After control Na+ current was recorded. DEX was added to the extracellular solution. Yohimbine and prazosin were used to differentiate the contribution of ƒ¿2-adrenergic receptor from that of ƒ¿1-adrenergic receptor. The peak TTX-r Na+ currents were significantly and dose dependently inhibited by DEX(p<0.05). Yohimbine attenuated the suppressive effects of DEX on TTX-r Na+ currents, while prazosin did not alter the effects of DEX. Thus, DEX inhibited TTX-r Na+ currents by way of ƒ¿2-adrenergic receptors but not aladrenerglc receptors. Therefore, it is suggested that DEX has an inhibitory effect on TTX-r Na+ channels through ƒ¿2-adrenergic receptors.
PracticeBasic medicine
Keywordstetrodotoxin-resistant sodium current, dorsal root ganglion neuron, dexmedetomldine, ƒ¿2-adrenergic receptor, ƒ¿1-adrenergic receptor

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