| Japanese |
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| Title | 心拍動下冠動脈バイパス術中の頻脈に対するランジオロールの効果 |
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| Subtitle | 症例 |
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| Authors | 安部和夫*, 岡淳子**, 宮川繁***, 竹内麦穂***, 吉龍正雄***, 福田浩嗣*** |
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| Authors(kana) | |
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| Organization | *桜橋渡辺病院麻酔科, **帝京大学医学部麻酔科, ***桜橋渡辺病院心臓血管外科
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| Journal | 循環制御 |
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| Volume | 26 |
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| Number | 3 |
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| Page | 247-250 |
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| Year/Month | 2005/9 |
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| Article | 報告 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 心拍動下バイパス術(OPCAB)中100回/分以上の上室性頻脈を呈した20例を対象にランジオロールの循環動態に及ぼす影響を検討した. 心拍数, 平均動脈圧, 中心静脈圧, 平均肺動脈圧, 混合静脈血酸素飽和度, 心拍出量をランジオロール投与開始前(T1), 開始後10分(T2), 20分(T3), 30分(T4)に測定した. 心拍数はランジオロール投与開始前112±8回/分であったが投与開始後10分で98±10回/分, 投与開始後20分で91±9回/分, 30分で86±7回/分と有意に減少した. 平均動脈圧は投与開始前74±16mmHgと比べ開始後10分で67±13mmHgと有意に低下したが, それ以上の低下は認められなかった. 以上の結果はランジオロールはOPCAB中の上室性頻脈の改善に有用であることを示唆している. 冠動脈疾患に対する心拍動下冠動脈バイパス術(OPCAB)は本邦においてもひろく行われている. この手術の麻酔経過中に上室性頻脈性不整脈になると心筋の酸素需要を上昇させ心筋虚血を増強する危険性があるため, 早急に治療する必要がある. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | |
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| English |
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| Title | The Effect of Landiolol on Tachycardia During Off-Pump Coronary Artery Bypass Graft |
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| Authors | Kazuo Abe*, Junko Oka**, Shigeru Miyagawa***, Mugiho Takeuchi***, Masao Yoshitatsu***, Hirotsugu Fukuda*** |
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| Authors(kana) | |
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| Organization | *Department of Anesthesiology, Sakurabashi Watanabe Hospital, **Department of Anesthesiology, Teikyo University Medical School, ***Department of Cardiovascular Surgery, Sakurabashi Watanabe Hospital
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| Journal | Circulation Control |
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| Volume | 26 |
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| Number | 3 |
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| Page | 247-250 |
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| Year/Month | 2005/9 |
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| Article | Report |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | The administration of an ultra-short acting β1 blocker has been introduced as a novel method for the treatment of supraventricular tachycardia during cardiac surgery. In the present study, the effect of ultra-short acting β1 blocker, landiolol, on tachycardia during off-pump coronary artery bypass graft was investigated. Landiolol 0.125mg/kg was injected intravenously and landiolol 0.04mg/kg/min was infused continuously for 30 minutes in twenty patients who were scheduled for off-pump CABG and demonstrated supraventricular tachycardia (100bpm<) during the preparation of intra thoracic artery. At 10min after the start of ladiolol infusion, the heart rate was significantly decreased from 112±8 to 98 ±l0bpm and the mean artery blood pressure was significantly decreased from 74±16 to 67±13mmHg. Other hemodynamic parameters did not significantly change during ladiolol infusion. These results may suggest the efficacy of ladiolol for reducing tachycardia during off-pump CABG. |
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| Practice | Basic medicine |
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| Keywords | landiolol, off-pump CABG, supraventricular tachycardia |
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