| English |
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| Title | Sevoflurane does not confer additive cardioprotection on early ischemic preconditioning in rabbit hearts |
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| Authors | Mitsuru Ohdachi, Naofumi Nishida, Munetaka Furuya, Kazu-ichi Yoshida |
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| Organization | Division of Anesthesiology, Department of Clinical Care Medicine, Kanagawa Dental College
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| Journal | Circulation Control |
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| Volume | 26 |
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| Number | 4 |
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| Page | 314-321 |
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| Year/Month | 2005/12 |
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| Article | ΄ |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | The present study aimed to compare the cardioprotective potencies of sevoflurane and ischemic preconditioning (IP) in vivo rabbit hearts. All anesthetized open-chest rabbits underwent 30 min of left anterior descending coronary artery (LAD) occlusion followed by 3 h of reperfusion. Before this, rabbits were randomized into one of six groups. Control rabbits received no intervention for 45 min before LAD occlusion and reperfusion (control; n=5). The ischemiapreconditioned (IN rabbits underwent 5 min LAD occlusion followed by 10 min of reperfusion (IP; n=5). In the sevoflurane (S) group, 30 min of sevoflurane exposure at a 1.5% end-tidal concentration was followed by 15 min of washout (S, n=5). The selective mitochondorial KATP channel blocker, 5-hydroxydecanoate (5-HD, 5 mg/kg) was given intravenously 10 min before ischemic preconditioning and sevoflurane exposure, respectively, (5-HD+IP; n = 5, 5-HD+S; n =5). In the sevoflurane-plus-IP group, rabbits received 30 min of sevoflurane exposure at a 1.5% endtidal concentration followed by 15 min of washout before 5 min LAD occlusion and 10 min of reperfusion (S+IP; n = 5). At the end of the 3-h reperfusion period, area at risk and infarct size were measured. There were no differences in systemic hemodynamics among 6 groups. The area at risk showed no significant differences during baseline conditions among experimental groups. Mean infarct size was 67.4 }1.5% (mean}SD) of the risk area in untreated controls. The mean infarct size was significantly smaller in the IP, S, and S+IP groups: 41.2}0.9%, 49.7}4.6%, and 40.9}3.6%, respectively (P<0.05 vs. control). In contrast, mean infarct size was 56.7}2.1% in the 5HD+IP group, and 61.6}2.8% in the 5-HD+S group. Sevoflurane-induced preconditioning as well as IP exerts infarct size limiting effect through opening of mitochondrial KATP channels. Our data suggest that there is no additive effect of sevoflurane on IP induced cardioprotection. |
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| Practice | Basic medicine |
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| Keywords | Sevoflurane, Anesthetic-induced preconditioning, Ischemic preconditioning, Cardioprotection, Heart infarct size |
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