| Japanese |
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| Title | Prediction of Cibenzoline Dose from that of Digoxin |
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| Subtitle | |
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| Authors | Ryuji Kato*, Yuka Shimeda*, Takako Nishihori*, Yuri Tsukura*, Kyoko Fukumoto**, Kazuyuki Ueno**, Takashi Umeda***, Yoshihiko Hirotani*, Kazuhiko Tanaka* |
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| Authors(kana) | |
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| Organization | *Department of Clinical Pharmacy and Clinical Pharmacokinetics, Osaka University of Pharmaceutical Sciences, **Department of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, ***Department of Clinical Acupuncture, Kansai College of Oriental Medicine
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| Journal | 循環制御 |
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| Volume | 27 |
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| Number | 1 |
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| Page | 55-60 |
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| Year/Month | 2006/3 |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | In clinical use, digoxin and cibenzoline are prescribed together for the treatment of cardiac arrhythmias. They are mainly excreted unchanged in urine, and their rates of excretion are similar. It has therefore been suggested that the pharmacokinetics of digoxin can predict that of cibenzoline. The aim of this study was to examine the possibility of prediction of cibenzoline dose from that of digoxin. We retrospectively examined 141 Japanese inpatients who received treatment for atrial fibrillation after cardiac surgery in the National Cardiovascular Center from April 2000 to December 2002. We found that CIBCL/F increased in proportion to DxCL/F. We obtained and evaluated a formula to predict cibenzoline dose from that of digoxin. If the dosage predicted from the formula was administered, about 70% patients could be maintained within the therapeutic range. The formula obtained in this study, which can predict cibenzoline dose from that of digoxin, should thus be very valuable in clinical practice. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | cibenzoline, digoxin, dose, prediction, formula |
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