Japanese
Titleラットの脳死モデルにおける心機能変化
Subtitle
Authors岩崎光生, 林行雄, 上林卓彦, 真下節
Authors(kana)
Organization大阪大学大学院医学系研究科, 麻酔集中治療医学講座
Journal循環制御
Volume28
Number3
Page210-215
Year/Month2007/9
Article原著
Publisher日本循環制御医学会
Abstract脳死後の心機能低下のメカニズムを検討する前提として, ラットの脳死モデルを用いて脳死後の心機能の変化を調べた. ラットの頭蓋内にフォガティカテーテルを挿入, 膨らませて脳死状態を導入した群とセボフルレン麻酔で維持した群に分け, 左心室の圧-容量曲線を描出し, 心機能の変化を比較した. セボフルレン群では6時間後まで血圧は保たれ生存率は100%だったが, 脳死群では50%であった. 脳死群では一過性にMAPが上昇した後低下し, 6時間後に有意な低下が見られたが, それより早期に駆出率, dP/dT max(脳死3時間後)の有意な低下が見られた.
Practice基礎医学・関連科学
Keywordsbrain death, cardiac function
English
TitleCardiac Function Following Experimental Brain Death in Rats
Subtitle
AuthorsMitsuo Iwasaki, Yukio Hayashi, Takahiko Kamibayashi, Takashi Mashimo
Authors(kana)
OrganizationDepartment of Anesthesiology, Osaka University Medical School
JournalCirculation Control
Volume28
Number3
Page210-215
Year/Month2007/9
ArticleOriginal article
PublisherJapan Society of Circulation Control
AbstractWe investigated the cardiac function following experimental brain death in rats. Rats were anesthetized with sevoflurane. Experimental brain death was induced by inflating intracranial balloon and sevoflurane was discontinued after brain death. Control rats were continuously anesthetized without balloon. We inserted micro-tip catheter and conductance catheter into LV to measure cardiac function every 30 min following brain death. Although mean blood pressure and heart rate was relatively maintained until 330 min following brain death, ejection fraction and dP/dT max significantly reduced 180 min after brain death. Only fifty percent of rats survived 6 hours after brain death, while no control rats died. Our results suggest that cardiac function after brain death is impaired much earlier before blood pressure reduction becomes apparent.
PracticeBasic medicine
Keywordsbrain death, cardiac function

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