| English |
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| Title | Capsaicin Improves Survival Rate in Mice with Lipopolysaccharide-Induced Endotoxin Shock |
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| Authors | Yuri Tsukura*, Yuko Takabatake*, Hanako Nakazato*, Ryuji Kato*, Yoshio Ijiri*, Kazuhiko Tanaka* |
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| Authors(kana) | |
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| Organization | *Department of Clinical Pharmacy and Clinical Pharmacokinetics, Osaka University of Pharmaceutical Sciences |
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| Journal | Circulation Control |
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| Volume | 28 |
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| Number | 4 |
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| Page | 307-313 |
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| Year/Month | 2007/12 |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | Capsaicin (Cap) has been reported to inhibit endotoxin-induced production of cytokines and NOx in vitro. In this study, we investigated the effects of Cap on endotoxin-induced shock mice. Lipopolysaccharide (LPS) from Escherichia coli was administered to male BALB/c mice intraperitoneally (i.p.) and Cap was administered subcutaneously (s.c.). Survival of mice was monitored at intervals of 24 hours for 7 days and serum levels of tumor necrosis factor-alpha (TNF-α), interleukin-1beta (IL-1β) , and nitrite/ nitrate (NOx) were measured after LPS administration (20mg/kg, i.p.). Treatment with Cap (4mg/kg, s.c.) at 5 min after LPS administration to the mice significantly improved the rate of 7-day survival rate from 0.0 to 91.7%(p＜0.001). However, treatment with Cap at one hour before LPS administration did not improve the survival rate. Cap reduced area under the response curve (AUC) by 41% for TNF-α(p＜0.01), 61% for IL-1β(p＜0.05), and 76.1% for NOx (p＜0.05) in endotoxemic mice. These findings suggest that Cap administration may be beneficial during sepsis. |
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| Practice | Basic medicine |
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| Keywords | capsaicin, lipopolysaccharide, tumor necrosis factor-alpha, endotoxin shock, interleukin-1beta, nitric oxide |
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