| Japanese |
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| Title | Intravenous Administration of Acetated Ringer's Solution Containing Magnesium and 1% Glucose during Neurosurgery |
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| Subtitle | |
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| Authors | Yasuharu Kosaka, Hirotsugu Okamoto, Tetsuo Ueno, Sumio Hoka |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology, Kitasato University School of Medicine |
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| Journal | 循環制御 |
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| Volume | 29 |
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| Number | 1 |
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| Page | 56-62 |
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| Year/Month | 2008/5 |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | Lactated Ringer's solution and acetated Ringer's solution are used for extracellular fluid replacement during neurosurgery. Since these solutions are glucose and Mg-free, they may precipitate potentially serious complications partly due to hypomagnesemia. We compared newly-available Mg and 1% glucose containing acetated Ringer's solution with conventional Ringer's solution by measuring ionized Mg concentration, glucose metabolism, rate of occurrence of arrhythmia and hypertension, and neurological outcome during neurosurgery. Sixty patients scheduled for neurosurgery were randomly assigned into three equal groups; those who received acetated Ringer's solution containing 1% glucose and Mg (Group 1) , lactated Ringer's solution (Group 2) , and acetated Ringer's solution (Group 3) . The ionized Mg blood concentration was maintained in Group 1 while gradual falls were observed in both Group 2 and Group 3. Although a slight rise in blood glucose was observed in the Group 1, no profound hyperglycemia was noted. The incidence of arrhythmia and hypertension, and the neurological outcome, were not different among the groups. We conclude that acetated Ringer's solution containing Mg and 1% glucose seems effective in maintaining blood Mg concentration without causing profound hyperglycemia, hypertension, or lethal arrhythmia during neurosurgery. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | magnesium, glucose, neurosurgery, pyruvate, fatty acid |
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