| Japanese |
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| Title | 緊急手術となった急性大動脈疾患の手術侵襲に対するシベレスタットナトリウムの有用性 |
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| Subtitle | 原著 |
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| Authors | 汐口壮一*, 入江嘉仁**, 権重好**, 田中恒有**, 大喜多陽平**, 今関隆雄** |
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| Authors(kana) | |
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| Organization | *騎西クリニック病院循環器血管外科, **獨協医科大学越谷病院心臓血管外科 |
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| Journal | 循環制御 |
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| Volume | 30 |
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| Number | 1 |
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| Page | 19-24 |
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| Year/Month | 2009/5 |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 『要旨』 急性大動脈疾患の手術侵襲で炎症性サイトカインの過剰産生により全身性炎症反応症候群(Systemic inflammatory response syndrome：SIRS)を誘起し, 臓器障害のため, 術後管理に難渋する症例を経験する. 我々は急性大動脈疾患で緊急手術を行った21症例に対し好中球エラスターゼ阻害薬シベレスタットナトリウム(以下シベレスタット)を使用し臓器障害に対する影響を検討した. シベレスタットの術前投与はDICの発症を軽減させ, 急性期の好中球エラスターゼ活性と過凝固状態を有意に抑制した. SOFA(Sequential organ failure assessment)スコア比較では術前投与群と術後投与群に有意な差は認められなかったが急性大動脈疾患の緊急手術症例に対する術前からのシベレスタットの投与は臓器障害を軽減する可能性が示唆された. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | 急性大動脈疾患, シベレスタットナトリウム, 好中球エラスターゼ, acute aortic syndrome, sivelestat sodium, neutrophil elastase |
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| English |
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| Title | Effects of Sivelestat Sodium on Perioperative Organ Function in Acute Aortic Syndrome |
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| Subtitle | |
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| Authors | Soichi Shioguchi*, Yoshihito Irie**, Shigeyoshi Gon**, Koyu Tanaka**, Yohei Okita**, Takao Imazeki** |
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| Authors(kana) | |
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| Organization | *Department of Cardiovascular Surgery, Kisai Clinic Hospital, **Department of Cardiovascular Surgery, Dokkyo Medical University Koshigaya Hospital |
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| Journal | Circulation Control |
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| Volume | 30 |
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| Number | 1 |
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| Page | 19-24 |
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| Year/Month | 2009/5 |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | Acute aortic syndrome is responsible for an overproduction of inflammatory cytokines, due not only to the bodily onslaught brought about by its clinical condition, but also to the development of systemic inflammatory response syndrome (SIRS), leading to the onset of multiple organ failure and difficulties in postoperative management. In the current study, the efficacy of Sivelestat sodium, a neutrophil elastase inhibitor, was evaluated on sequential organ failure assessment (SOFA) after emergency surgery in acute aortic syndrome. The subjects were 21 patients who developed acute aortic syndrome and underwent emergency surgery between August 2006 and December 2007. Starting the administration of Sivelestat sodium before surgery to patients with acute aortic syndrome could reduce the augmentation of inflammatory mediator and factors related to the coagulation-fibrinolysis system. Although SOFA score and lung injury scores were not significantly different between pre-operative and post-operative use of Sivelestat sodium, DIC was significantly suppressed in the pre-operative use of Sivelestat sodium were effectively suppressed in the pre-operative use as compared with the post-operative use. It is suggested that pre-operative initiation of Sivelestat sodium may be effective for organ protection in acute aortic syndrome. |
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| Practice | Basic medicine |
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| Keywords | acute aortic syndrome, sivelestat sodium, neutrophil elastase |
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