| Japanese |
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| Title | 麻酔開胸犬の対照状態と血漿カテコールアミン濃度 |
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| Authors | 斎藤隆雄*, 太田憲宏**, 神山有史*, 坂田正策***, 高田和子*, 土井敏彦***, 山田泰史***, 中原俊之***, 篠原祥三*, 北畑洋*, 玉西利範* |
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| Authors(kana) | |
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| Organization | *徳島大学医学部麻酔紅教室, **徳島大学医学部救急部, ***徳島大学医学部手術部 |
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| Journal | 循環制御 |
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| Volume | 5 |
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| Number | 4 |
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| Page | 465-471 |
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| Year/Month | 1984/ |
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| Article | 原著 |
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| Publisher | 日本循環制御研究会 |
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| Abstract | 実験動物のどのような状態がいわゆる対照として適切かについては議論が多い1)〜4). 全身麻酔下に開胸, 各種プローブ, カテーテルを取りつけ, 全身状態が落ちついたところを対照として薬剤投与や各種操作の影響を見る方法は, 問題があるとされながらも今なお血行動態の研究に多用されている. 問題点のひとつは開胸手術の侵襲に対して, 質, 量とも適当な麻酔が必ずしも行われていないためか, 個体によっては甚だしい循環過働状態が見られることである. われわれは麻酔開胸犬の対照状態研究の一環として, 血漿カテコールアミン濃度を測定し, 麻酔法や血行状態との関連を検討したので報告する. 「方法」冠循環観察の目的で開胸, 左冠動脈幹, 大動脈起始部に電磁血流計プローブを装着, 右外頸静脈から冠静脈洞へ採血用カテーテル, 右大腿動脈および腋窩動脈から各1本のMillar社製MIKRO-TIP PC 370型トランスデューサをそれぞれ上行大動脈および左心室に, 左大腿動脈および同静脈経由下大静脈に採血用カテーテル, 右大腿動脈に静注用カテーテルを挿入した状態の雑種成犬20頭(体重12.5±2.4kg)を対象にした. |
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| Practice | 基礎医学・関連科学 |
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| English |
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| Title | Sympathoadrenal Response to Thoractomy in The Anesthetized Dog |
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| Authors | Takao Saito, Norihiro Ohta, Arifumi Kohyama, Seisaku Sakata, Kazuko Takada, Toshihiko Doi, Yasuhito Yamada, Toshiyuki Nakahara, Shozo Shinohara, Hiroshi Kitahata, Toshinori Tamanishi |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology Tokushima University school of Medicine |
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| Journal | Circulation Control |
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| Volume | 5 |
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| Number | 4 |
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| Page | 465-471 |
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| Year/Month | 1984/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | Changes in plasma catecholamine concentrations were observed in twenty acutely thoracotomized dogs, and related to their own circulatory responses in the study. Anesthesia was induced with 300-500 mg of intravenous thiamylal and maintained with inhalation of halothane and nitrous oxide (GOF). Either 20 mg of morphine or 0.2mg of buprenorphine was given intravenously for two groups consist of six animals, respectively (groups II and III), while with the remaining eight anesthesia was maintained by GOF alone (group I). Heart rate, plasma epinephrine as well as norepinephrine concentrations rose markedly and significantly by thoracotomy under anesthesia. The hyperdynamic state of the circulation seemed closely correlated with plasma catecholamine concentrations, especially that of epinephrine. The increase in sympathoadrenal activity seemed to be roughly estimated by counting heart rate, even without measuring catecholamine concentrations. The responses varied with individual animals, and probably because of this variation, difference in anesthesia did not produce significant differences in circulatory as well as sympathoadrenal responses to thoraetomy in the study. |
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| Practice | Basic medicine |
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| Keywords | plasma catecholamines, thoracotomy, basal status |
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