| Japanese |
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| Title | 全身温熱療法の安全性に関する研究―臓器血流量の変化について― |
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| Authors | 田中彰, 増谷正人, 能見登志恵 |
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| Organization | 鳥取大学医学部麻酔科 |
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| Journal | 循環制御 |
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| Volume | 9 |
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| Number | 4 |
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| Page | 483-488 |
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| Year/Month | 1988/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 雑種成犬を用い, 高体温（41℃）下における, 臓器血流量の変化をマイクロスフェア法を用いて測定した. 臓器血流量は, 脳, 左室心筋, 心室中隔心筋, で増加したが, 肝固有血流量, 腎, 胃, 小腸, 大腸では変化する事なく保たれていた. 一方, 直腸, 脾, 筋肉, 皮膚の血流量は, 高体温下で有意に減少した. 重要臓器の血流が, 保たれていたことから, 臓器循環に関する限り, 高体温療法は一応安全であると考えられた. しかし, 門脈血流は低下することから, 高体温下で発生する肝障害の原因として, 熱による障害以外に, 肝血流の低下によるものの可能性が示唆された. |
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| Practice | 基礎医学・関連科学 |
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| English |
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| Title | The Effect of Total Body Hyperthemia on Organ Blood Flow |
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| Authors | Akira Tanaka, Masato Masutani, Tosie Noumi |
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| Organization | Department of Anesthesiology, Tottori University, School of Medicine |
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| Journal | Circulation Control |
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| Volume | 9 |
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| Number | 4 |
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| Page | 483-488 |
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| Year/Month | 1988/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | This work was done to evaluate the changes of the organ blood flow during hyperthermia （41℃）. Eleven mongrel dogs were anesthetized and warmed up to 41℃ by means of surface warming as well as trans−airway warming. Organ blood flow was measured by radio−active microsphere method. 1）The organ blood increased in brain, left ventricular myocardium and ventricular septal myocardium at 41℃, but did not change in liver, kidney, stomach, small intestine and large intestine, However, organ blood flow decreased in spleen, rectum, muscles and skin. 2）No significant co−relation were observed between changes of the organ blood flow and plasma cathecolamin level. 3）Significant reduction of the blood flow in portal organs suggests that hypoperfusion of the liver as well as the direct heat injury may play an important role as a major factor in the development of liver damage during hyperthermia. |
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| Practice | Basic medicine |
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| Keywords | Total body hyperthermia, Organ blood flow, Norepinephrine, Epinephrine |
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