| Japanese |
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| Title | 冠動脈狭窄・脱血犬の血行動態に及ぼす2−［（5−Chloro−2−methoxyphenyl）azo］−1H−imidazole（M6434）の効果―フェニレフリン, ドブタミンとの比較― |
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| Authors | 宇野幸彦*, 手塚新吉*, 森田茂穂**, 川端博秋*, 郡彰一*, 矢萩真弓*, 岡田和夫* |
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| Authors(kana) | |
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| Organization | *帝京大学医学部麻酔学教室, **帝京大学附属市原病院麻酔学教室 |
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| Journal | 循環制御 |
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| Volume | 9 |
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| Number | 4 |
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| Page | 495-502 |
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| Year/Month | 1988/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 冠動脈狭窄・脱血犬を用い, 血行動態に及ぼす2−［（5−Chloro−2−methoxyphenyl）azo］−1H−imidazole（M6434）の効果について検討し, その作用をフェニレフリン, ドブタミンの作用と比較した. M6434投与による血行動態の変化は, 全般にフェニレフリン投与後の変化に類似し, ドブタミン投与による血行動態の変化とは左室拡張終期圧, 心拍数, 末梢血管抵抗係数において最も大きな相違が認められた. 3薬剤のいずれも, 脱血により低下した平均動脈圧を脱血前値まで上昇させ, それに伴い左冠動脈回旋枝血流量も脱血前値に回復した. しかし一心拍あたりの回旋枝血流量の回復という観点からは, M6434, フェニレフリンはドブタミンよりも有効と考えられ, 本剤の冠動脈疾患における有用性が示唆された. |
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| Practice | 基礎医学・関連科学 |
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| English |
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| Title | Effects of 2−［（5−Chloro−2−methoxyphenyl）azo］−1H−imidazole（M6434） on hemodynamics in hemorrhagic dogs with coronary stenosis―Comparison with phenylephrine and dobutamine― |
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| Subtitle | |
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| Authors | Yukihiko Uno, Shinkichi Tezuka, Shigeho Morita, Hiroaki Kawabata, Shoichi Kori, Mayumi Yahagi, Kazuo Okada |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology, Teikyo University School of Medicine |
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| Journal | Circulation Control |
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| Volume | 9 |
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| Number | 4 |
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| Page | 495-502 |
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| Year/Month | 1988/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | Hemodynamic effects of M6434, a potent vasopressor, were evaluated in hemorrhagic hypotensive dogs with coronary artery stenosis. Mongrel dogs（n＝28） were subjected to left thoracotomy, and left circumflex coronary artery was narrowed to about 50％ of control flow, and then, mean arterial blood pressure was kept at approximately 60％ by bleeding. After obtaining steady state condition, M6434 was infused at the rate ranging from 0.5 to 3.0μg／kg／min. Mean arterial blood pressure and narrowed coronary flow were increased to the pre−bleeding value by M6434 infusion （1.0〜1.5μg／kg／min）. Similar hemodynamic alterations were observed when phenylephrine was infused. Dobutamine increased mean arterial blood pressure and the coronary flow as well, but marked increase in heart rate was observed which was not observed in M6434 and phenylephrine infusion. These results indicate that M6434 may have a preferable effect to maintain coronary flow in terms of preservation of ischemic myocardium. |
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| Practice | Basic medicine |
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