| Japanese |
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| Title | TNG, PGE1低血圧麻酔時の頭蓋内環境変化の検討 |
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| Subtitle | 原著 |
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| Authors | 水間謙三*, 川村隆枝**, 岡田一敏**, 岡田弘**, 秋山潤根**, 涌澤玲児**, 樫本威志* |
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| Authors(kana) | |
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| Organization | *岩手医科大学医学部薬理学教室, **岩手医科大学医学部麻酔学教室 |
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| Journal | 循環制御 |
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| Volume | 17 |
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| Number | 2 |
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| Page | 230-234 |
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| Year/Month | 1996/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」頭蓋内環境への低血圧麻酔の影響を検討する目的で, ハロタン, 笑気麻酔イヌに, 静注用ニトログリセリン(TNG)またはプロスタグランディンE1(PGE1)を持続静注し, 平均血圧を1/3および1/2低下させ, 局所脳皮質血流量(rCBF), 頭蓋内圧(ICP)と局所脳酸素飽和度(rSO2)を測定した. その結果, 両群ともrCBFは変化せず, 自己調節機構は保たれていた. しかし, TNG低血圧ではICPとrSO2は同時に上昇したが, ICPは20分以内に回復したもののrSO2は高値を維持した. PGE1低血圧ではrSO2は変化せず, ICPは低下した. これらの結果には, 降圧薬の頭蓋内血管に対する作用が異なるためと, ICP変化に対する静脈容積や脳脊髄液などの代償作用が関与している可能性が推察された. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | Hypotensive anesthesia, Intracranial Pressure, Cerebral blood flow, Cerebral oxygen saturation, Nitroglycerin, Prostaglandin E1 |
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| English |
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| Title | The Changes of Intracranial Pressure, Cerebral Blood Flow and Cerebral Oxygen Saturation during Hypotensive Anesthesia ―Comparison of Nitroglycerin and Prostaglandin E1― |
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| Subtitle | |
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| Authors | Kenzo Mizuma*, Takae Kawamura**, Kazutoshi Okada**, Hiroshi Okada**, Zyunne Akiyama**, Reiji Wakusawa**, Takeshi Kashimoto* |
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| Authors(kana) | |
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| Organization | *Departments of Pharmacology, Iwate Medical University School of Medicine, **Departments of Anesthesiology, Iwate Medical University School of Medicine |
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| Journal | Circulation Control |
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| Volume | 17 |
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| Number | 2 |
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| Page | 230-234 |
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| Year/Month | 1996/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | The effects of hypotension induced by nitroglycerin (TNG group) or prostaglandin E1 (PGE1 group) on intracranial pressure (ICP), regional cerebral blood flow (rCBF) and regional cerebral oxygen saturation (rSO2) were evaluated in mongrel dogs anesthetized with 1% halothane and 66% nitrous oxide under normocarbic (PaCO2 36-38 mmHg) and normothermic (37℃) condition. TNG or PGE1 was infused intravenously for 2 hours and the mean arterial pressure was reduced to about 66% or 50% of the base line level for 1 hour. ICP increased transient but significantly soon after hypotension, but recovered to the control level in the TNG treated group (P<0.05). However, it decreased significantly during hypotension in the PGE1 group (P<0.02). rSO2 increased significantly during hypotension with TNG but not in the PGE1 group (P<0.05). rCBF did not change significantly during hypotension with either TNG or PGE1. These results suggest that hypotensive anesthesia induced by PGE1 seems to be a safer and more reliable method than TNG for neuroanesthesia. (Circ Cont 17：230〜234, 1996) |
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| Practice | Basic medicine |
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| Keywords | Hypotensive anesthesia, Intracranial Pressure, Cerebral blood flow, Cerebral oxygen saturation, Nitroglycerin, Prostaglandin E1 |
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