| Japanese |
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| Title | 開心術後症例におけるアムリノンの脳循環に及ぼす影響 |
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| Subtitle | 原著 |
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| Authors | 原智子*, 倉迫敏明**, 武藤純***, 鷹取誠***, 多田恵一*** |
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| Authors(kana) | |
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| Organization | *国家公務員共済組合連合会呉共済病院麻酔科, **岡山大学医学部麻酔・蘇生学教室, ***社会保険広島市民病院麻酔・集中治療科 |
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| Journal | 循環制御 |
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| Volume | 18 |
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| Number | 1 |
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| Page | 15-19 |
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| Year/Month | 1997/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」開心術後症例に対しアムリノンを持続静注し, その脳灌流に及ぼす影響について酸素摂取率の変化より検討した. 対象は開心術後症例11例, 麻酔は大量フェンタニール麻酔にて行い, 麻酔終了2時間後よりアムリノンを5μg・kg-1・min-1にて持続投与した. 投与開始前より開始後3時間まで心拍出量測定及び動脈血, 混合静脈血, 内頸静脈血の血液ガス分析を行い, 体酸素摂取率(OER), 脳酸素摂取率(Br-OER), 脳体酸素摂取率比(OERratio)を算出した. アムリノン持続投与にて, OERは心係数の変化に伴って変化するも, Br-OERはほぼ一定に保たれ, アムリノンにより体循環に及ぼされる影響に関わらず, 脳循環は維持されると考えられた. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | Amrinone, Cerebral circulation, Oxygen extraction ratio, Autoregulatory mechanism. |
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| English |
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| Title | Effect of Amrinone on Cerebral Circulation after Open Heart Surgery |
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| Subtitle | |
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| Authors | Tomoko Hara*, Toshiaki Kurasako**, Jun Muto***, Makoto Takatori***, Keiichi Tada*** |
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| Organization | *Department of Anesthesiology, Kure Kyosai Hospital, **Department of Anesthesiology and Resuscitology, Okayama University Medical School, ***Department of Anesthesiology and Intensive Care, Hiroshima City Hospital |
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| Journal | Circulation Control |
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| Volume | 18 |
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| Number | 1 |
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| Page | 15-19 |
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| Year/Month | 1997/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | We discussed on the cerebral circulation by measuring change of oxygen extraction ratio after administration of amrinone. We administrated amrinone to 11 patients who underwent open heart surgery. Five μg・kg-1・min-1 of amrinone was started by continuous infusion 2 hours after the end of the operation. We measured cardiac output, gas analysis, of arterial, mixed venous, and internal jugular blood sample at following 5 points (Before, and 30min, 1hr, 2hr, 3hr after the amrinone infusion). Whole body oxygen extraction ratio (OER), cerebral oxygen extraction ratio (Br-OER), OER ratio (Br-OER/OER) were calculated from these measured parameters. Throughout this study period, change of OER was consistent to the change of cardiac output (0.3 ± 0.04 to 0.27 ± 0.11). Whereas, Br-OER remained relatively constant (0.43 ± 0.12 to 0.42 ± 0.10). We conclue that cerebral oxygen demand/supply ratio is maintained constant during the amrinone infusion, suggesting that amrinone may preserve autoregulatory mechanism of cerebral circulation. (Circ Cont 18：15〜19, 1997) |
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| Practice | Basic medicine |
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| Keywords | Amrinone, Cerebral circulation, Oxygen extraction ratio, Autoregulatory mechanism. |
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