| Japanese |
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| Title | エピネフリン併用時の虚血再灌流不整脈に及ぼすハロタンの影響 |
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| Subtitle | 原著 |
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| Authors | 坂口雅彦*1, 中村正人*2, 楳田高士*1, 田倉学*1, 福喜多邦夫*3, 小野稔*2, 古賀義久*1 |
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| Authors(kana) | |
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| Organization | *1近畿大学医学部麻酔科学教室, *2市立貝塚病院麻酔科, *3国立大阪南病院麻酔科 |
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| Journal | 循環制御 |
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| Volume | 18 |
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| Number | 3 |
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| Page | 390-397 |
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| Year/Month | 1997/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要約」ラット摘出心における虚血再灌流モデルで, エピネフリン併用時のハロタンの再灌流不整脈に及ぼす影響について検討した. 実験は, Langendorff法による冠灌流を行い, 左冠状動脈前下行枝を6分間結紮閉塞させ, その後, 結紮の解除によって再灌流を行った. 再灌流時に発生する心室性の再灌流不整脈については, エピネフリン単独投与時, エピネフリン・ハロタン併用は各々について, 心室細動を指標としてその発現頻度, 持続時間について比較検討した. エピネフリン単独投与群においては, 10-5mol/lで最も心室細動の発現頻度が多かった. ハロタンは, エピネフリン併用投与下の再灌流時において, 10-6, 10-5mol/lの濃度でVFの発現頻度, 持続時間に抑制効果を示した. ハロタンは, エピネフリン投与下の再灌流不整脈に対して抑制効果を持つことが示された. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | Epinephrine, Halothane, Reperfusion-induced arrhythmia, Ischemia |
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| English |
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| Title | Can Halothane Inhibit Reperfusion-induced Arrhythmias in Isolated Perfused Rat Heart when Epinephrine Is Given Simultaneously? |
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| Subtitle | |
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| Authors | Masahiko Sakaguchi*1, Masato Nakamura*2, Takashi Umeda*1, Manabu Takura*1, Kunio Fukukita*3, Minoru Ono*2, Yoshihisa Koga*1 |
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| Authors(kana) | |
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| Organization | *1Departments of Anesthesiology, Kinki University School of Medicine, *2Kaizuka City Hospital, *3Osaka-Minami National Hospital |
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| Journal | Circulation Control |
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| Volume | 18 |
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| Number | 3 |
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| Page | 390-397 |
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| Year/Month | 1997/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | Using the isolated perfused rat heart, we have investigated the influence of halothane on the reperfusion-induced arrhythmias when epinephrinne is given simultaneously. Isolated rat hearts (n=108) were subjected to regional ischemia (occlusion of left anterior descending coronary artery for 6 minutes) and reperfusion (3 minutes). The incidence and the duration of ventricular fibrillation (VF) which arrised at the reperfusion period were studied as parameters of reperfusion-induced arrhythmias. When epinephrine was administered individually, the incidence of VF and the duration of VF increased in the concentration of 10-7 to 10-5 mol/l. But the concomitant use of 2MAC of halothane with epinephrine caused the reduction of both the incidence and the duration of reperfusion-induced VF compared with those when the same doses of epinephrine were given independently. The results of the present study indicate that epinephrine enhances the reperfusioninduced arrhythmias, but that halothane can inhibit reperfusion-induced arrythmias, but that halothane can inhibit reperfusion-induced arrhythmias even in the presence of epinephrine . |
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| Practice | Basic medicine |
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| Keywords | Epinephrine, Halothane, Reperfusion-induced arrhythmia, Ischemia |
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