| Japanese |
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| Title | 出血性ショックにおける一酸化窒素合成酵素阻害薬の投与が臓器血流分布に及ぼす影響 |
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| Subtitle | 原著 |
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| Authors | 藤岡丞 |
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| Authors(kana) | |
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| Organization | 帝京大学医学部麻酔学教室 |
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| Journal | 循環制御 |
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| Volume | 18 |
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| Number | 4 |
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| Page | 541-547 |
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| Year/Month | 1997/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」出血性ショックにおけるNO合成酵素(NOS)阻害薬の投与が全身の臓器血流分布に及ぼす影響を放射性マイクロスフェア法を用いて検討した. イヌ16頭を対象に, 脱血により平均血圧40mmHgを90分間維持した後L-NAME10mg/kg(L-NAME群)および生理食塩水(対照群)を投与した. 投与15分後の臓器血流分布をショック前と比較した. ショックに伴う血流分布の変化に両群間で有意差を認めた臓器はなく, L-NAME群でも脳, 心臓への血流シフトは保たれた. ただし肝臓では対照群で見られた血流分布率増加がL-NAME群では見られず, NOS阻害薬が肝臓には不利である可能性もあると考えられた. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | Nitric oxide synthase inhibitor, Hemorrhagic shock, Blood organ flow istribution |
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| English |
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| Title | Effects of Nitric Oxide Synthase Inhibitor on Organ Blood Flow Distribution during Hemorrhagic Shock |
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| Subtitle | |
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| Authors | Susumu Fujioka |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology, Teikyo University School of Medicine |
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| Journal | Circulation Control |
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| Volume | 18 |
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| Number | 4 |
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| Page | 541-547 |
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| Year/Month | 1997/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | The present paper investigated the effects of nitric oxide synthase (NOS) inhibitor on organ blood flow distribution during hemorrhagic shock. In sevoflurane anesthetized dogs, hypotension (mean arterial pressure =40mmHg) was achieved by draining blood from their circulation into a reservoir. Hypotension was maintained within this range for 90 min by further removing or transfusing blood. Following the 90 min shock period, 10mg/kg N-nitro-L-arginine methyl ester (L-NAME group : n=8) or saline (control group : n=8) was administered. Organ blood flow distribution was measured before hypotension and 15min after L-NAME or saline administration in both groups by the radioactive microsphere method. There was no signicant difference in organ blood flow distribution between the two groups. A physiological shift in blood flow distribution during hemorrhagic shock to the brain and heart (centralization) was observed in both groups. Fractional blood flow to the liver increased significantly more in the control group than in the L-NAME group. These results suggest that the NOS inhibitor does not strongly affect on blood flow distribution, but can negatively affect the liver during hemorrhagic shock. |
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| Practice | Basic medicine |
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| Keywords | Nitric oxide synthase inhibitor, Hemorrhagic shock, Blood organ flow distribution |
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