| Japanese |
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| Title | カルシトニン遺伝子関連ペプチドによるビーグルにおける低血圧麻酔時の全身的および局所的血行動態への影響 |
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| Subtitle | |
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| Authors | 原島敏也* |
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| Authors(kana) | |
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| Organization | *帝京大学医学部麻酔科学講座 |
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| Journal | 循環制御 |
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| Volume | 19 |
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| Number | 3 |
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| Page | 406-411 |
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| Year/Month | 1998/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」カルシトニン遺伝子関連ペプチド(CGRP)は中枢神経や各臓器に存在するニューロペプチドで, 強い血管拡張作用を有する. セボフルラン麻酔下のイヌにおいて, CGRPによる低血圧時の全身的及び局所的血行動態について検討した. 全身的には心係数, 1回拍出量係数が増加し, 心拍数, 体血管抵抗が減少した. 局所的には肝, 脾血流量が増加し, 他の重要臓器血流は維持された. セボフルラン麻酔下のイヌで, CGRPは重要臓器の血流を損なうことなく, 後負荷減少により血圧を低下させた. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | |
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| English |
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| Title | Effects of Calcitonin Gene-related Peptide Induced Hypotension on Systemic and Regional Hemodyamics during Sevoflurane Anesthesia in Beagles |
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| Subtitle | |
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| Authors | Toshiya Harashima* |
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| Authors(kana) | |
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| Organization | *Department of Anesthesiology, Teikyo University School of Medicine |
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| Journal | Circulation Control |
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| Volume | 19 |
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| Number | 3 |
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| Page | 406-411 |
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| Year/Month | 1998/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | Calcitonin gene-related peptide (CGRP) is a neuropeptide which is widely prcsent in central nervous system and various organs and known to have a potent vasodilating action. Changes in systemic hemodynamics and microsphere-determined regional blood flow were examined during 30% reduction in mean arterial pressure using CGRP in beagles under sevoflurane anesthesia. Following administration of CGRP, cardiac index and stroke volume index in creased but heart rate and systemic vascular resistance decreased. With regards to regional hemodynamics, blood flow to the liver via the hepatic artery and spleen increased, whereas those to other vital organs were unchanged. These results suggested that CGRP depressed the blood pressure through decreases of after-load without affecting the blood flow to the vital organs. |
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| Practice | Basic medicine |
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| Keywords | Calcitonin gene-related peptide, Induced hypotension, Organ blood flow |
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