| Japanese |
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| Title | ウサギ体性刺激および内臓刺激時の血圧上昇に対するプロポフォール投与下におけるクロニジンの抑制効果 |
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| Subtitle | |
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| Authors | 一戸達也*, 金子譲* |
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| Authors(kana) | |
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| Organization | *東京歯科大学歯科麻酔学講座 |
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| Journal | 循環制御 |
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| Volume | 20 |
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| Number | 4 |
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| Page | 404-409 |
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| Year/Month | 1999/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」ウサギのオトガイ神経(体性刺激)および胃壁電気刺激(内臓刺激)時の血圧上昇に対するプロポフォール投与下におけるクロニジンの抑制効果を検討した. 電気刺激は50Hz, 0.5msecの矩形波で5秒間行い, 刺激強度はオトガイ神経が5V, 胃壁が30Vとした. プロポフォール200μg/kg/min投与下を対照とし, さらにクロニジンを0.33, 0.67, 1.33μg/kg/minの順で投与し, その後ヨヒンビン400μg/kgを投与した. 各時期の収縮期圧(SBP)の刺激前値から刺激後最大値への上昇量(△SBP)を記録した. オトガイ神経および胃壁電気刺激時の△SBPは両者ともクロニジン投与量依存性に抑制され, ヨヒンビン投与で対照値に回復した. プロポフォール投与下において, クロニジンはオトガイ神経および胃壁電気刺激時の血圧変動に対して同程度の抑制効果を示した. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | |
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| English |
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| Title | Clonidine Inhibits Blood Pressure Elevation Mediated by Electrical Stimulation of the Mental Nerve and the Gastric Wall in the Rabbit under Propofol Anesthesia |
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| Subtitle | |
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| Authors | Tatsuya Ichinohe*, Yuzuru Kaneko* |
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| Authors(kana) | |
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| Organization | *Department of Dental Anesthesiology, Tokyo Dental College |
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| Journal | Circulation Control |
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| Volume | 20 |
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| Number | 4 |
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| Page | 404-409 |
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| Year/Month | 1999/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | Inhibitory effects of clonidine on blood pressure elevation mediated by electrical stimulation of the mental nerve and the gasuic wall were investigated in male Japan White rabbits anesthetized with propofol. The control measurements were performed under a continuous infusion of propofol (200μg/kg/min). Clonidine was infused at either rate of 0.33, 0.67 or 1.33 μg/kg/min for 60 minutes. Then, yohimbine 400 μg/kg was injected. The increases in systolic blood pressure (SBP) by the stimulation (△SBP=maximum SBP during electrical stimulation - SBP at prestimulation) were inhibited by clonidine in a dosedependent manner. △SBPs at the control period were 44.8 ± 5.8 mmHg (mean ± SEM) for the mental nerve stimulation and 24.3 ± 3.9 mmHg for the gastric wall stimulation, respectively. The percentages of △SBP during the mental nerve and the gastric wall stimulations were similarly inhibited by clonidme. The percentage inhibitions of △SBP at the rate of 1.33μg/kg/min clonidine were 48.5 ± 11.5% for the mental nerve stimulation and 44.5 ± 8.2% for the gastric wall stimulation, respectively. |
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| Practice | Basic medicine |
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| Keywords | Propofol, Clonidine, Somatic and visceral noxious stimulation, Blood pressure response |
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