| Japanese |
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| Title | 高血圧は早期に冠動脈血管抵抗を上昇させる−腹部大動脈クリッピング高血圧ラット肥大心モデルにおける検討− |
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| Subtitle | 原著 |
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| Authors | 嶌田泰之 |
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| Authors(kana) | |
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| Organization | 京都府立医科大学心臓血管外科 |
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| Journal | 循環制御 |
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| Volume | 24 |
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| Number | 2 |
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| Page | 131-134 |
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| Year/Month | 2003/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」【目的】高血圧, 心肥大の進展とともに冠循環の悪化がいつ出現するのか, 実験的検討を行うこと. 【方法】ラット腹部大動脈にクリップにて狭窄を作成し, 高血圧モデルを作成. 【成績】頸動脈血圧は, 術後2週目から有意に上昇. 左室重量, 冠動脈血管抵抗は, 術後1週目から有意に上昇. 虚血後の左室駆出圧, 左室拡張終期圧は有意差を認めなかった. 【結語】本モデルにおいて, 左室への圧負荷は, 高血圧が進行する前から, 左室肥大を招き, 早期に冠循環を悪化させた. 虚血後の左室機能には影響はなかったものの, 冠動脈血管抵抗の上昇は冠動脈バイパスには不利と思われる. 高血圧の早期から冠循環障害は認められうるので, 冠動脈保護のために早期からの降圧治療が必要と考える. 「はじめに」心臓肥大は心血管事故の重要な危険因子とされている1). 著者らはこれまで高血圧による左室肥大が致命的不整脈(虚血再灌流による)を招き, 冠循環も悪化させることを実験的に示してきた2,3). |
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| Practice | 基礎医学・関連科学 |
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| Keywords | 心肥大, 虚血再灌流障害, 冠循環, 心機能, ラット, Left ventricular hypertrophy, Coronary vascular resistance, Coronary bypass surgery, Rat |
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| English |
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| Title | Effects of Ventricular Hypertrophy on Coronary Circulatin and Post-ischemic Cardiac Function in Rat Heart |
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| Subtitle | |
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| Authors | Yasuyuki Shimada |
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| Organization | Cardiovascular Surgery, Kyoto Prefectural University of Medicine |
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| Journal | Circulation Control |
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| Volume | 24 |
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| Number | 2 |
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| Page | 131-134 |
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| Year/Month | 2003/ |
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| Article | Report |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | We studied coronary circulation in pressure overload-induced left ventricular (LV) hypertrophy. Wistar male rats (n=6/group) were subjected to abdominal aortic constriction or to sham-operation. At 1, 2 and 3 weeks after surgery, we measured blood pressure in the carotid artery in vivo. The hearts were isolated and subjected to Langendorf perfusion. After 15 min of global ischemia, hearts were perfused for 45 min. LV developing pressure (LVDP), LV end-diastolic pressure (LVEDP), coronary vascular resistance (mmHg/ml/min) and heart weight were determined. Aortic constriction resulted in a significant increase in blood pressure at 2 and 3 weeks after surgery. LV weight, and coronary vascular resistance significantly increased at 1, 2, and 3 weeks after surgery. LVDP and LVEDP did not change significantly throughout study period. These results suggest that LV pressure overload deteriorates coronary circulation quickly and that early stage anti-hypertensive treatment may be important for maintenance of coronary circulation. |
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| Practice | Basic medicine |
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| Keywords | Left ventricular hypertrophy, Coronary vascular resistance, Coronary bypass surgery, Rat |
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